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Naproxen

Naproxen Suppliers list
Company Name: Henan Tianfu Chemical Co.,Ltd.
Tel: 0371-55170693
Email: info@tianfuchem.com
Products Intro: CAS:22204-53-1
Purity:99% Package:500G;1KG;5KG;25KG
Company Name: Shanghai Bojing Chemical Co.,Ltd.
Tel: +86-21-37122233
Email: Candy@bj-chem.com
Products Intro: Product Name:Naproxen
CAS:22204-53-1
Purity:99% Package:1Kg;25kg/ Drum or as customer request
Company Name: Wuhan Wsem Biological Co., Ltd.  Gold
Tel:027-59402396 ; 13419635609
Email:13419635609@163.com
Products Intro:Product Name:Naproxen
CAS:22204-53-1
Purity:99.9% Package:1G 50G 1KG 25KG
Company Name: J & K SCIENTIFIC LTD.  
Tel:400-666-7788 +86-10-82848833
Email:jkinfo@jkchemical.com;market6@jkchemical.com
Products Intro:Product Name:Naproxen
CAS:22204-53-1
Purity:98% Package:1G,250MG
Company Name: Meryer (Shanghai) Chemical Technology Co., Ltd.  
Tel:+86-(0)21-61259100(Shanghai) +86-(0)755-86170099(ShenZhen) +86-(0)10-62670440(Beijing)
Email:sh@meryer.com
Products Intro:Product Name:(S)-(+)-6-Methoxy-α-Methyl-2-naphthaleneacetic acid
CAS:22204-53-1
Purity:98% Package:500g Remarks:AAA125549
Naproxen Basic information
Non-steroidal anti-inflammatory drugs Chemical Properties Uses Used in Particular Diseases production method Category Toxicity grading Acute toxicity Flammability and hazard characteristics Storage Characteristics Extinguishing agent
Product Name:Naproxen
Synonyms:()-2-(methoxy-2-naphthyl)-propionicacid;()-2-(methoxy-2-naphthyl)-propionsaeure;()-propionicaci;(+)-2-(Methoxy-2-naphthyl)-propionic acid;(+)-2-(methoxy-2-naphthyl)-propionicacid;(+)-2-(Methoxy-2-naphthyl)-propionsaeure;(+)-2-naphthaleneaceticaci;(+)-6-Methoxy-alpha-methyl-2-napthaleneacetic acid
CAS:22204-53-1
MF:C14H14O3
MW:230.26
EINECS:244-838-7
Product Categories:chiral;Carboxylic Acids (Chiral);Chiral Building Blocks;for Resolution of Bases;Optical Resolution;Synthetic Organic Chemistry;Intermediates & Fine Chemicals;Pharmaceuticals;Lipid signaling;Aromatics;ALEVE;Other APIs
Mol File:22204-53-1.mol
Naproxen Structure
Naproxen Chemical Properties
Melting point 152-154 °C(lit.)
alpha D +66° (in chloroform)
refractive index 67.5 ° (C=1, CHCl3)
Fp 9℃
storage temp. -20°C Freezer
Water Solubility Insoluble in water.
Merck 14,6417
BRN 3591067
CAS DataBase Reference22204-53-1(CAS DataBase Reference)
NIST Chemistry ReferenceNaproxen(22204-53-1)
Safety Information
Hazard Codes Xn,T,F
Risk Statements 22-39/23/24/25-23/24/25-11-36/37/38
Safety Statements 36/37-45-16-7-26
RIDADR UN 2811 6.1/PG 3
WGK Germany 3
RTECS UF5275000
HazardClass 6.1(b)
PackingGroup III
Hazardous Substances Data22204-53-1(Hazardous Substances Data)
MSDS Information
ProviderLanguage
(+)-2-(6-Methoxy-2-naphthyl)-propionic acid English
SigmaAldrich English
ALFA English
Naproxen Usage And Synthesis
Non-steroidal anti-inflammatory drugsNaproxen is a non-steroidal anti-inflammatory drug ,it is a PG synthase inhibitor, which can inhibit prostaglandin synthetase, it has significant analgesic and antipyretic effects, oral absorption is rapid and complete, 2 to 4 hours after a dose ,plasma concentration reaches the peak, in the blood , more than 99% is bound to plasma proteins, t1/2 is 13 to 14 hours, about 95% is discharged from the urine with the prototype and metabolites.it is clinically used For the treatment of rheumatic and rheumatoid arthritis , osteoarthritis, ankylosing spondylitis, gout, arthritis, tenosynovitis.it can also be used to alleviate pain caused by musculoskeletal sprains, contusions,damages and dysmenorrhea . But it should be noted that like other non-steroidal anti-inflammatory drugs, the same serious gastrointestinal adverse reactions could occur at any time while taking naproxen during treatment, so the active gastroduodenal ulcer patients are hanged, other gastrointestinal tract disease patients should take this drug under close medical supervision.
The above information is edited by the Chemicalbook of Tian Ye.
Chemical PropertiesWhite crystal or crystalline powder. Melting point 155.3 ℃. Soluble in acetone, soluble in methanol, ethanol, acetic acid, insoluble in benzene, practically insoluble in water. In case of light,it is color-graded, odorless, tasteless.
UsesIt is a non-steroidal anti-inflammatory drug for the relief of fever and inflammation and pain associated with arthritis or other symptoms , it has anti-inflammatory, antipyretic and analgesic effects. Naproxen plays a role by inhibiting the cyclooxygenase, which generates prostaglandin and is one kind of enzymes related to inflammatory mediators . It is recommended to take the drug during meals to reduce stomach irritation.
Used in Particular DiseasesAcute Gouty Arthritis:
Dosage and Frequency: 500 mg twice daily for 3 days, then 250–500 mg daily for 4–7 days
production methodby methylation, acetylation With 2-naphthol , 6-methoxy-2-acetonaphthone is produced, then it is condensed with acid ester, then generate the product through isomerization, hydrolysis, oxidation, and split and other reactions.
CategoryToxic substances
Toxicity gradingHighly toxic
Acute toxicityOral-rat LD50 248 mg/kg; Oral-Mouse LD50: 360 mg/kg
Flammability and hazard characteristicsCombustible; combustion produces toxic and acrid smoke.
Storage CharacteristicsVentilated, low-temperature ,dry storeroom, it should be stored and transported from food raw materials separately.
Extinguishing agentWater, dry powder, foam,sand
Chemical Propertieswhite to light yellow crystal powde
UsesAn anti-inflammatory, analgesic, antipyretic. A non-steroidal anti-inflammatory
DefinitionChEBI: A methoxynaphthalene that is 2-methoxynaphthalene substituted by a carboxy ethyl group at position 6. Naproxen is a non-steroidal anti-inflammatory drug commonly used for the reduction of pain, fever, inflammation and stiffness caused by conditions such a osteoarthritis, kidney stones, rheumatoid arthritis, psoriatic arthritis, gout, ankylosing spondylitis, menstrual cramps, tendinitis, bursitis, and for the treatment of primary dysmenorrhea. It works by inhibiting both the COX-1 and COX-2 enzymes.
Naproxen Preparation Products And Raw materials
Raw materialsMethanol-->Toluene-->Hydrogen-->2-Naphthol-->2-Acetyl-6-methoxynaphthalene
Preparation ProductsNaproxen sodium
Tag:Naproxen(22204-53-1) Related Product Information
4-(NITROOXY)BUTYL (2S)-2-(6-METHOXY-2-NAPHTHYL)PROPANOATE (2R)-2-AMINO-2-(6-METHOXY(2-NAPHTHYL))PROPANOIC ACID NAPROXEN, [O-METHYL-14C] Naproxen Thiophanate-methyl Methoxy Methyl Methyl bromide p-Anisidine 2-Naphthylacetic acid Kresoxim-methyl Methylparaben Anisic acid p-Anisaldehyde Methyl acrylate DL-Thioctic acid 1-Naphthalene acetic acid Bensulfuron methyl