- (R)-2-Flurbiprofen
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- $0.00 / 25KG
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2023-08-12
- CAS:51543-40-9
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 50000KG/month
- (R)-2-Flurbiprofen
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- $10.00 / 1KG
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2023-03-29
- CAS:51543-40-9
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 10 mt
- (R)-2-Flurbiprofen
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- $90.00 / 1KG
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2021-11-15
- CAS:51543-40-9
- Min. Order: 10KG
- Purity: 99.9%
- Supply Ability: 100tons
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| | (R)-2-Flurbiprofen Basic information |
| Product Name: | (R)-2-Flurbiprofen | | Synonyms: | (R)-2-Fluoro-α-methyl-1,1'-biphenyl-4-acetic acid;(R)-α-Methyl-2-fluoro-1,1'-biphenyl-4-acetic acid;(R)-(-)-2-Fluoro-alpha-methyl-4-biphenylacetic acid (Flurbiprofe;[1,1'-Biphenyl]-4-aceticacid, 2-fluoro-a-Methyl-,(aR)-;MPC 7869;(R)-(-)-2-Fluoro-alpha-methyl-4-biphenylacetic acid 97%;(R)-Flurbiprofen, >=99%;(R)-2-Flurbiprofenr | | CAS: | 51543-40-9 | | MF: | C15H13FO2 | | MW: | 244.26 | | EINECS: | 257-264-7 | | Product Categories: | API;Pharmaceutical ingredients | | Mol File: | 51543-40-9.mol |  |
| | (R)-2-Flurbiprofen Chemical Properties |
| Melting point | 110-113 °C(lit.) | | Boiling point | 376.2±30.0 °C(Predicted) | | density | 1.199±0.06 g/cm3(Predicted) | | storage temp. | Store at RT | | solubility | DMF: 25 mg/ml; DMSO: 10 mg/ml; Ethanol: 25 mg/ml; PBS (pH 7.2): .9 mg/ml | | pka | 4.14±0.10(Predicted) | | form | Crystalline Powder | | color | White to off-white |
| Hazard Codes | T | | Risk Statements | 25 | | Safety Statements | 26-36/37/39-45 | | RIDADR | UN 2811 6.1/PG 2 | | WGK Germany | 3 | | HS Code | 29163900 |
| | (R)-2-Flurbiprofen Usage And Synthesis |
| Description | (R)-Flurbiprofen is a COX-inactive enantiomer of the racemic non-selective COX inhibitor flurbiprofen that has diverse biological activities. It inhibits γ-secretase activity in vitro and, in vivo, it reduces formation of amyloid-β peptide 1-42 (Aβ42) and improves axonal transport in young Aβ-plaque free mice but not old mice with existing Aβ plaques in the Tg2576 transgenic model of Alzheimer''s disease. (R)-Flurbiprofen inhibits NF-kB activation and DNA binding as well as AP-1 DNA binding in RAW 264.7 macrophages and reduces paw edema in a rat model of zymosan-induced inflammation via COX-independent inhibition of NF-κB and AP-1 activation when administered at doses of 1, 3, and 9 mg/kg. It also suppresses prostate tumor cell growth in vitro by inducing p75NTR protein expression and reduces tumor growth and metastasis in multiple mouse models of intestinal neoplasia. | | Uses | (R)-2-Flurbiprofen is the R-isomer of Flurbiprofen (F598700), an anti-inflammatory used as an analgesic. | | Definition | ChEBI: (R)-flurbiprofen is a flurbiprofen. It is an enantiomer of a (S)-flurbiprofen. | | Biochem/physiol Actions | gamma secretase inhibitor; amyloid Abeta 42 lowering agent |
| | (R)-2-Flurbiprofen Preparation Products And Raw materials |
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