3,3-二(4-羟基苯基)-2(3H)-吲哚酮
| 中文名称 | 3,3-二(4-羟基苯基)-2(3H)-吲哚酮 |
|---|---|
| 中文同义词 | 酚丁;酚汀;3,3-二(4-羟基苯基)-2(3H)-吲哚酮;二酚靛红;氧苯尼司汀;化合物 T7071;3,3-双(4-羟基苯基)吲哚啉-2-酮;乙腈中酚汀标准溶液 |
| 英文名称 | 3,3-BIS(P-HYDROXYPHENYL)OXINDOLE |
| 英文同义词 | 3,3-Bis(4-hydroxyphenyl)indoline-2-one;3,3-bis(4-hydroxyphenyl)-1H-indol-2-one;3,3-Bis(4-Hydroxsyphenyl)-2(3H)-Indolone;3,3-Bis(4-hydroxyphenyl)-1,3-dihydro-2H-indol-2-one;recolon;veripaque;3,3-bis(4-hydroxyphenyl)indolin-2-one;3,3-BIS(4-HYDROXYPHENYL)-2-INDOLINONE |
| CAS号 | 125-13-3 |
| 分子式 | C20H15NO3 |
| 分子量 | 317.34 |
| EINECS号 | 204-728-1 |
| 相关类别 | |
| Mol文件 | 125-13-3.mol |
| 结构式 |  |
3,3-二(4-羟基苯基)-2(3H)-吲哚酮 性质
| 熔点 | 260-261 °C |
|---|---|
| 沸点 | 562.9±50.0 °C(Predicted) |
| 密度 | 1.352±0.06 g/cm3(Predicted) |
| 储存条件 | Store at -20°C |
| 溶解度 | 二甲基亚砜：≥28mg/mL（88.23mM） |
| 酸度系数(pKa) | 9.42±0.30(Predicted) |
Oxyphenisatine (Oxyphenisatin) 是一种泻药。 Oxyphenisatin acetate是具有抗癌活性的氧联苯沙星的前体药。
Oxyphenisatin has been shown to have antiproliferative activity. Oxyphenisatin acetate (OXY, NSC 59687) is the pro-drug of oxyphenisatin. OXY inhibits the growth of the breast cancer cell lines MCF7, T47D, HS578T, and MDA-MB-468 (IC 50 =0.8, 0.6, 2.1, 1.8 μM). This effect is associated with selective inhibition of translation accompanied by rapid phosphorylation of the nutrient sensing eIF2α kinases, GCN2 and PERK.
Toxicity studies demonstrate that mice tolerate IP administration of OXY at 300 mg/kg once daily or 200 mg/kg twice daily. Administration of OXY at 300 mg/kg IP once daily for 10 days results in significantly smaller tumors from day 33 to day 52.
化学性质
结晶。熔点 ＞260℃。用途
三醋酚汀的中间体。生产方法
用靛红与苯酚在浓硫酸作用下缩合制得。安全信息
上游原料