醛固酮
| 中文名称 | 醛固酮 |
|---|---|
| 中文同义词 | 醛固酮溶液,100PPM;醛固醇酮;醛甾酮;醛固酮;醛固酮(+4℃);醛固酮(溶液)[干冰运输];醛固酮[干冰运输];非标记醛固酮(化学纯度95%) |
| 英文名称 | ALDOSTERONE |
| 英文同义词 | ELECTROCORTIN;11,21-Dihydroxy-3,20-dioxopregn-4-en-18-al;11beta,21-Dihydroxy-3,20-dioxo-pregn-4-en-18-al;18-Oxocorticosterone;21-dihydroxy-3,20-dioxo-1(11-beta)-pregn-4-en-18-a;21-dihydroxy-3,20-dioxo-1(11beta)-pregn-4-en-18-a;Aldocorten;Aldocortene |
| CAS号 | 52-39-1 |
| 分子式 | C21H28O5 |
| 分子量 | 360.45 |
| EINECS号 | 200-139-9 |
| 相关类别 | 化学试剂;内分泌系列;细胞生物学;标准品;对照品;生化试剂-其他化学试剂;化工原料;临床检测标准物质;Steroids;Intermediates & Fine Chemicals;Isotope Labeled Compounds;Steroid Hormones;A-AM;Aldehydes;Bioactive Small Molecules;Building Blocks;C13-C60;Carbonyl Compounds;Cell Biology;Cell Signaling and Neuroscience;Chemical Synthesis;Cytokines;Hormones;Organic Building Blocks;TPI;Pharmaceuticals;Corticosteroid;Growth Factors and Hormones;Isolabel |
| Mol文件 | 52-39-1.mol |
| 结构式 |  |
醛固酮 性质
| 熔点 | 170-172°C |
|---|---|
| 比旋光度 | D23 +152.2° (anhydr; c = 2 in acetone); D25 +161° (c = 0.1 in chloroform) |
| 沸点 | 412.46°C (rough estimate) |
| 密度 | 1.28 |
| 折射率 | 1.6120 (estimate) |
| 闪点 | 2℃ |
| 储存条件 | Sealed in dry,Room Temperature |
| 溶解度 | 可溶于丙酮（轻微）、氯仿（轻微）、DMSO（轻微）、甲醇（轻微） |
| 酸度系数(pKa) | 12.98±0.10(Predicted) |
| 形态 | 结晶粉末 |
| 颜色 | 白色 |
| 水溶解性 | 51.18mg/L(37 ºC) |
| Merck | 13,224 |
| BRN | 3224996 |
| CAS 数据库 | 52-39-1(CAS DataBase Reference) |
| EPA化学物质信息 | Aldosterone (52-39-1) |
Aldosterone 是原发性盐皮质激素。Aldosterone 是一种类固醇激素，通过肾上腺皮质的肾小球区 (ZG) 对肾素-血管紧张素系统激活 (RAS) 或高钾饮食反应而合成和分泌。Aldosterone 活性在细胞水平上依赖于胞浆/核盐皮质激素受体 (MR) 的结合和激活。
|
Human Endogenous Metabolite
|
Aldosterone (1-1000 nM; 24 hours) inhibits interleukin-1β-stimulated nitrite production by vascular smooth muscle cells in a dose-dependent manner.
Aldosterone (1 mg/Kg+1% NaCl; i.h.; once daily for 3 weeks) significantly increases systolic blood pressure (SBP), diastolic blood pressure (DBP), left ventricular systolic pressure (LVSP) and left ventricular end-diastolic pressure (LVEDP).
Aldosterone (0.72 mg/kg/day; 14 days) causes a small increase ( 14 mmHg) in blood pressure in male mice.
| Animal Model: | Forty male Wistar rats |
| Dosage: | 1 mg/Kg (+1% NaCl) |
| Administration: | i.h.; once daily for 3 weeks |
| Result: | Systolic blood pressure (SBP), diastolic blood pressure (DBP), left ventricular systolic pressure (LVSP) and left ventricular end-diastolic pressure (LVEDP) were significantly higher in aldosterone-salt-treated animals. |
类别
有毒物品可燃性危险特性
易燃; 燃烧排放刺激烟雾储运特性
库房通风低温干燥; 与食品添加剂分开存放灭火剂
泡沫,沙土,二氧化碳,干粉, 雾状水安全信息
| 危险品标志 | Xi,Xn,F |
|---|---|
| 危险类别码 | 36/37/38-36-20/21/22-11 |
| 安全说明 | 22-24/25-36-26-36/37-16 |
| 危险品运输编号 | UN 1648 3 / PGII |
| WGK Germany | 3 |
| RTECS号 | TU4523000 |
| F | 22-24-25 |
| 海关编码 | 29372900 |
| 提供商 | 语言 |
|---|---|
|
英文
|
|
|
英文
|