ML-9盐酸盐
| 中文名称 | ML-9盐酸盐 |
|---|---|
| 中文同义词 | 1-(5-氯萘磺酰基)-1H-六氢-1,4-二氮杂卓, 盐酸盐;1-(5-氯萘-1-磺酰基)-1H-六氢-1,4-二吖庚因盐酸盐;ML-9盐酸盐;1-((5-氯萘-1-基)磺酰基)-1,4-二氮杂环庚烷盐酸盐;ML-9,蛋白激酶抑制剂 |
| 英文名称 | ML-9 HYDROCHLORIDE |
| 英文同义词 | ML-9;ML-9 HYDROCHLORIDE;1-(5-CHLORONAPHTHALENE-1-SULFONYL)-1H-HEXAHYDRO-1,4-DIAZEPINE HCL;1-(5-CHLORONAPHTHALENE-1-SULFONYL)-1H-HEXAHYDRO-1,4-DIAZEPINE HYDROCHLORIDE;1-(5-CHLORONAPHTHALENE-1-SULFONYL)HOMOPIPERAZINE, HCL;1-(5-CHLORONAPHTHALENESULFONYL)-1H-HEXAHYDRO-1,4-DIAZEPINE, HYDROCHLORIDE;1-(5-CHLORONAPHTHALENESULFONYL)HOMOPIPERAZINE HYDROCHLORIDE;1-(5-CHLORONAPHTHALENESULPHONYL)-1H-HEXAHYDRO-1,4-DIAZEPINE HYDROCHLORIDE |
| CAS号 | 105637-50-1 |
| 分子式 | C15H18Cl2N2O2S |
| 分子量 | 361.28 |
| EINECS号 | 200-258-5 |
| 相关类别 | 生化试剂;Protein Kinase Inhibitors and Activators |
| Mol文件 | 105637-50-1.mol |
| 结构式 |  |
ML-9盐酸盐 性质
| 熔点 | 196-200 |
|---|---|
| 储存条件 | 2-8°C |
| 溶解度 | 乙醇：10 mg/mL |
| 形态 | 粉末 |
| 颜色 | 白色 |
ML-9 HCl (ML-9 hydrochloride) 是一种有效的选择性的 Akt kinase、myosin light chain kinase (MLCK) 和 stromal interaction molecule 1 (STIM1)。ML-9 HCl 也是 Ca2+-permeable channels 的有效抑制剂。ML-9 HCl 是一种靶向自噬和细胞死亡的亲溶酶体剂。
| Target | Value |
|
Akt
() | |
|
MLCK
() | |
|
STIM1
() | |
|
Ca2+-permeable channels
() |
ML9 (0-100 μM; 0-24 hours) has no reduction in cardiomyocyte viability, 50-100 μM significantly induces cell death. ML9 (50 μM; 1-4 hours) significantly increases cleaved caspase-3 levels, decreased STIM1 protein levels by about 42%.
Cell Viability Assay
| Cell Line: | Neonatal rat ventricular myocytes (NRVM) cells |
| Concentration: | 0, 10, 50 and 100 μM |
| Incubation Time: | 0, 1, 4, 8 and 24 hours |
| Result: | Decreased cell viability at 50-100 μM concentration. |
Apoptosis Analysis
| Cell Line: | Neonatal rat ventricular myocytes (NRVM) cells |
| Concentration: | 50 μM |
| Incubation Time: | 1, 4 and 8 hours |
| Result: | Induced cardiomyocyte death through necrosis and apoptosis. |
安全信息
| WGK Germany | 3 |
|---|---|
| Hazard Note | Harmful |
| 海关编码 | 2935909099 |
| 提供商 | 语言 |
|---|---|
|
英文
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| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/04/30 | HY-100932 | ML-9 | 5 mg | 440元 | |
| 2024/04/30 | HY-100932 | ML-9盐酸盐 ML-9 | 105637-50-1 | 10mM * 1mLin DMSO | 484元 |