ALPHA-玉米赤霉烯醇
中文名称 | ALPHA-玉米赤霉烯醇 |
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中文同义词 | 玉米赤霉烯醇Α;Α-玉米赤霉烯醇溶液,1000PPM;Α-玉米赤霉烯醇溶液,100PPM;ALPHA-2,4二羟基- 6 - [10 -二羟基- 1 - 十一碳烯基]苯甲酸酯;ALPHA-玉米赤霉烯醇;2,4-二羟基- 6-(6Α,10-二羟基反式-)苯甲酸Μ-内酯;Α-玉米赤霉烯醇 标准品;ALFA-ZEARALENOL |
英文名称 | ALPHA-ZEARALENOL |
英文同义词 | Zearalenol, alpha-;2,4-Dihydroxy-6-(6α,10-dihydroxy-trans-1-undecenyl)benzoic acid μ-lactone solution;α-Zearalenol solution;Α-ZEARALENOL;ZEARALENOL;ALPHA-ZEARALENOL;α-Zearalenol,2,4-Dihydroxy-6-(6α,10-dihydroxy-trans-1-undecenyl)benzoic acid μ-lactone;2,4-Dihydroxy-6-(6α,10-dihydroxy-trans-1-undecenyl)benzoic acid μ-lactone |
CAS号 | 36455-72-8 |
分子式 | C18H24O5 |
分子量 | 320.38 |
EINECS号 | 828-728-1 |
相关类别 | 微生物代谢物;霉菌毒素类;细胞生物学;化工原料;对照品;Chiral Reagents;Heterocycles;Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals |
Mol文件 | 36455-72-8.mol |
结构式 |
ALPHA-玉米赤霉烯醇 性质
熔点 | 158-161°C |
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沸点 | 599.0±50.0 °C(Predicted) |
密度 | 1.174±0.06 g/cm3(Predicted) |
闪点 | 2℃ |
储存条件 | -20°C |
溶解度 | 乙醇中≤20mg/ml;DMSO 中≤30mg/ml;二甲基甲酰胺中≤30mg/ml |
形态 | 结晶固体 |
酸度系数(pKa) | 7.61±0.60(Predicted) |
稳定性 | 吸湿性 |
α-Zearalenol (α-zol) (0.001-10 μM; 24-72 hours) shows the highest RPE (90.5%) at 9.37 µM α-ZOL exposure in MFC-7 cells with an IC 50 of 12.5 μM. α-Zearalenol (α-zol) (0.001-10 μM; 24-72 hours) induces an increase of cell viability on MCF-7 cells mainly after 72 h of treatment whereas it is slightly cytotoxic on MDA-MB231 cells. α-Zearalenol (α-zol) (0.001-10 μM; 24-72 hours) increases MCF7 cell population in the S phase and in the G2/M phase, no visible change in cell cycle phases is observed in MDA-MB231 cells. α-Zearalenol (α-zol) (1-10 μM; 24 hours) reduces the expression of TNF-α, α-ZOL combines with β-ZOL shows an antagonistic effect on inflammation for IL-1β and act synergic for IL-8 at high toxin concentrations.
Cell Proliferation Assay
Cell Line: | MFC-7 cells |
Concentration: | 6.25 µM-25 µM |
Incubation Time: | 24 hours |
Result: | Observed the highest RPE (90.5%) at 9.37 µM α-ZOL exposure in MFC-7 cells. |
Cell Viability Assay
Cell Line: | Breast cancer cell lines: MCF-7 and MDA-MB231 |
Concentration: | 0.001 μM, 0.1 μM and 10 μM |
Incubation Time: | 24 hours, 48 hours, 72 hours |
Result: | Modified the cell growth in two breast cancer cell lines. |
Cell Cycle Analysis
Cell Line: | MCF7 cells, MDA-MB231 cells |
Concentration: | 0.001 μM, 0.1 μM and 10 μM |
Incubation Time: | 72 hours |
Result: | Observed an increase of cells in cell cycle in MCF7 cells. |
RT-PCR
Cell Line: | HepG2 cells |
Concentration: | 1 μM, 5 μM, 10 μM |
Incubation Time: | 72 hours |
Result: | Induced a decrease of the expression of TNF-α, IL-1β and IL-8, that was in most cases statistically significant for the higher doses. |
安全信息
危险品标志 | Xn,T,F |
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危险类别码 | 20/21/22-40-52/53-68/20/21/22-36-11-62-48/20-63-46-45 |
安全说明 | 36/37-61-16-45-53 |
危险品运输编号 | UN 1648 3 / PGII |
WGK Germany | 3 |
F | 8 |
海关编码 | 29322090 |
提供商 | 语言 |
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英文
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更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/01/25 | HY-N6710 | α-Zearalenol | 1 mg | 1066元 | |
2024/01/25 | HY-N6710 | ALPHA-玉米赤霉烯醇 α-Zearalenol | 36455-72-8 | 5mg | 2800元 |