3-脱氮腺苷
中文名称 | 3-脱氮腺苷 |
---|---|
中文同义词 | 3-DEAZA-腺苷;3-氮杂腺;4-氨基-1-BETA-D-呋喃核糖基-1H-咪唑并[4,5-C]吡啶;3-脱氮腺苷;3-氮杂腺苷;3-脱氮腺苷(3-DZA) |
英文名称 | 3-DEAZAADENOSINE |
英文同义词 | 3-DEAZAADENOSINE;4-AMINO-1-[BETA-D-RIBOFURANOSYL]-1H-IMIDAZO[4,5]-PYRIDINE;4-Amino-1-(D-ribofuranosyl)-1H-imidazo(4,5)-pyridine;1H-Imidazo4,5-cpyridin-4-amine, 1-.beta.-D-ribofuranosyl-;3-Deaza-D-adenosine;NSC 167897;(2R,3R,4S,5R)-2-(4-AMino-1H-iMidazo[4,5-c]pyridin-1-yl)-5-(hydroxyMethyl)tetrahydrofuran-3,4-diol;3-Deaza-rA |
CAS号 | 6736-58-9 |
分子式 | C11H14N4O4 |
分子量 | 266.25 |
EINECS号 | |
相关类别 | 化学试剂;Bases & Related Reagents;Inhibitors;Nucleotides |
Mol文件 | 6736-58-9.mol |
结构式 |
3-脱氮腺苷 性质
熔点 | 228-229°C |
---|---|
沸点 | 665.7±65.0 °C(Predicted) |
密度 | 1.90±0.1 g/cm3 (20 ºC 760 Torr) |
储存条件 | Keep in dark place,Inert atmosphere,2-8°C |
溶解度 | H2O:10 mg/mL 加热至 60°C |
形态 | 固体 |
酸度系数(pKa) | 13.24±0.70(Predicted) |
颜色 | 白色至类白色 |
IC50: 0.15 (HIV-1, A012 isolate), 0.20 µM (HIV-1, A018 isolate)
Ki: 3.9 µM (S-adenosylhomocysteine hydrolase)
3-Deazaadenosine is an inhibitor of S-adenosylhomocysteine hydrolase, with a K i of 3.9 µM. 3-Deazaadenosine shows anti-HIV effect, and inhibits p24 antigen in peripheral blood mononuclear (PBMCs) cells infected with HIV-1 isolates (A012 and A018) with IC 50 s of 0.15 and 0.20 µM, respectively. 3-Deazaadenosine (1-100 µM) inhibits LPS-induced expression of TNF-α mRNA, increases DNA binding activity of NF-κB, and causes proteolytic degradation of IκBα, but Not IκBβ in RAW 264.7 cells. 3-Deazaadenosine (100 µM) enhances nuclear translocation of NF-κB, but blocks LPS-induced NF-κB transcriptional activity, and such inhibition is augmented by the addition of homocysteine. 3-Deazaadenosine (50, 100 µM) dose-dependently inhibits the phosphorylation of Raf and ERK, protein-dependent kinase 1, protein kinase B (Akt), and forkhead transcription factor FoxO1a. 3-Deazaadenosine (50 µM) suppresses vascular smooth muscle cell (VSMC) proliferation via interfering with Ras signaling.
安全信息
安全说明 | 24/25 |
---|---|
危险品运输编号 | 2811 |
WGK Germany | 3 |
危险等级 | 6.1(a) |
包装类别 | II |
海关编码 | 29419090 |
提供商 | 语言 |
---|---|
英文
|