- 1-Naphthyl isothiocyanate
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- $15.00 / 1KG
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2021-07-02
- CAS:551-06-4
- Min. Order: 1KG
- Purity: 99%+ HPLC
- Supply Ability: Monthly supply of 1 ton
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| | 1-Naphthyl isothiocyanate Basic information |
| | 1-Naphthyl isothiocyanate Chemical Properties |
| | 1-Naphthyl isothiocyanate Usage And Synthesis |
| Description | 1-Napthylisothiocyanate is a toxic chemical that has been used
to create experimental cholestasis in rodents. Laboratory
studies have also shown that 1-napthylisothiocyanate can act as
a chemoprotectant in rodents challenged with a tumorinducing
agent such as phorbol-12 myristate 13-acetate. | | Chemical Properties | white crystalline powder | | Uses | 1-Naphthyl isothiocyanate (NITC) can be used as a source of thiourea moiety to synthesize derivatives of calix[4]arenes to be used as anion acceptors. It can also be used for the synthesis of naphthyl substituted 1,2,4-triazoles and 1,3,4-thiadiazoles. | | Uses | 1-Naphthylisothiocyanate is used as an ingredient in insecticides.
It is also found in cyanamide, which is used in many
industrial applications. It is commonly used in medical and
drug studies in animals as a model hepatotoxicant producing
experimental cholestasis in rats and mice. | | Uses | 1-Naphthyl isothiocyanate is a tool for the study of liver damage which causes bile stasis and hyperbilirubinemia acutely and bile duct hyperplasia and biliary cirrhosis chronically, with changes in hepatocyte function. | | Definition | ChEBI: 1-naphthyl isothiocyanate is an isothiocyanate. It has a role as an insecticide. It derives from a hydride of a naphthalene. | | General Description | Odorless white needles or powder. Tasteless. | | Air & Water Reactions | 1-Naphthyl isothiocyanate is moisture sensitive. . Undergoes slow hydrolysis. Insoluble in water. | | Reactivity Profile | Isocyanates and thioisocyanates, such as 1-Naphthyl isothiocyanate, are incompatible with many classes of compounds, reacting exothermically to release toxic gases. Reactions with amines, aldehydes, alcohols, alkali metals, ketones, mercaptans, strong oxidizers, hydrides, phenols, and peroxides can cause vigorous releases of heat. Acids and bases initiate polymerization reactions in these materials. Some isocyanates react with water to form amines and liberate carbon dioxide. Base-catalysed reactions of isocyanates with alcohols should be carried out in inert solvents. Such reactions in the absence of solvents often occur with explosive violence, [Wischmeyer(1969)]. | | Fire Hazard | Flash point data for 1-Naphthyl isothiocyanate is not available, but 1-Naphthyl isothiocyanate is probably combustible. | | Environmental Fate | Naphthylisothiocyanate is moisture sensitive and insoluble in
water. The hydrolysis rate is slow. | | Purification Methods | Crystallise the isothiocyanate from hexane (1g in 9 mL). It forms white needles and is soluble in most organic solvents but is insoluble in H2O. It is absorbed through the skin and may cause dermatitis. [Cymmerman-Craig et al. Org Synth Coll Vol IV 700 1963, Beilstein 12 H 1244, 12 III 2948.] | | Toxicity evaluation | 1-Naphthylisothiocyanate causes separation of extracellular
tight junctions that seal bile canaliculi, impairing bile
formation. 1-Naphthylisothiocyanate inhibits microsomal
drug-metabolizing activity. In rats, 1-naphthylisothiocyanteglutathione
complex is formed in hepatocytes, then transported
to the bile ducts, where it is released from the glutathione, and
then selectively injures biliary epithelial cells, resulting in
reduced bile flow. |
| | 1-Naphthyl isothiocyanate Preparation Products And Raw materials |
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