鼠尾草苦内脂
中文名称 | 鼠尾草苦内脂 |
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中文同义词 | 鼠尾草酚;鼠尾草酚(标准品);鼠尾草苦内脂;鼠尾草酚(鼠尾草苦内脂);CARNOSOL 鼠尾草酚;鼠尾草苦内脂, 迷迭香中提取;鼠尾草酚 CARNOSOL;鼠尾草酚:鼠尾草苦内脂对照品, |
英文名称 | CARNOSOL |
英文同义词 | 1,3,4,9,10,10AS-HEXAHYDRO-5,6-DIHYDROXY-1,1-DIMETHYL-7-ISO-PROPYL-2H-9S,4AR-(EPOXYMETHANO)PHENANTHREN-12-ONE;1,3,4,9,10AS-HEXAHYDRO-5,6-DIHYDROXY-1,1-DIMETHYL-7-ISO-PROPYL-2H-9S,4AR-(EPOXYMETHANO)PHENANTHREN-12-ONE;1,2,3,4,4A,9,10,10AS-OCTAHYDRO-5,6-DIHYDROXY-1,1-DIMETHYL-7-ISOPROPYL-9S, 4AR (EPOXYMETHANO)PHENANTHREN-12-ONE;CARNOSOL(RG);CARNOSOL;Carnosol, froM RoseMarinus officinalis;Carnosol, 98%, from Rosemarinus officinalis;2H-9,4a-(Epoxymethano)phenanthren-12-one, 1,3,4,9,10,10a-hexahydro-5,6-dihydroxy-1,1-dimethyl-7-(1-methylethyl)-, (4aR,9S,10aS)- |
CAS号 | 5957-80-2 |
分子式 | C20H26O4 |
分子量 | 330.42 |
EINECS号 | |
植物来源 | 迷迭香 |
相关类别 | 植提标准品;膦配体;有机磷;对照品;中药对照品;Miscellaneous Natural Products;标准品;有机砌块;植物提取物;chemical reagent;pharmaceutical intermediate;标准品-中药标准品;标准品 -中药标准品;二萜;标准品,对照品;Antioxidant;Biochemicals Found in Plants;Nutrition Research;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract |
Mol文件 | 5957-80-2.mol |
结构式 |
鼠尾草苦内脂 性质
熔点 | 240~242℃ |
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沸点 | 524.8±50.0 °C(Predicted) |
密度 | 1.26±0.1 g/cm3(Predicted) |
储存条件 | Sealed in dry,Store in freezer, under -20°C |
溶解度 | DMSO:66.0(最大浓度 mg/mL);199.74(最大浓度 mM) |
酸度系数(pKa) | 8.91±0.40(Predicted) |
颜色 | 白色 |
LogP | 2.832 (est) |
鼠尾草苦内脂又叫鼠尾草酚,是一种存在于迷迭香和丹参等植物中的天然二萜化合物,具有很强的降血脂、抗氧化、抗肿瘤、抗病毒和抗炎特性,已广泛用于保健、食品、天然色素、化妆品等领域,据报道,鼠尾草苦内脂可以通过抑制NF-κB通路而具有抗肿瘤的作用,也可以诱导T细胞白血病、淋巴瘤细胞凋亡并降低血清中的IL-6和TNF-α水平。
取干燥的迷迭香枝叶2000g,加入石油醚14L,回流提取3次,每次3小时,合并3次提取液,浓缩回收石油醚,得浸膏;将浸膏用40%的乙醇溶解,过滤除去不溶物,得1000ml母液作为吸附液,以500mlD101大孔吸附树脂进行吸附,吸附完成后用1000ml纯化水通洗脱,再用1500ml90%乙醇溶液洗脱,洗脱液分为6段,合并中间的4份;合并的洗脱液减压浓缩至100ml,加水200ml,搅拌析出沉淀,放置3小时;离心得含鼠尾草苦内脂的沉淀;沉淀用200ml乙酸乙酯溶解,向其中加入200ml石油醚,搅拌,析出沉淀;过滤得鼠尾草苦内脂粗品,该粗品以800ml无水乙醇结晶,得到鼠尾草苦内脂结晶;过滤、干燥,得到结晶13.6g,HPLC检测鼠尾草苦内脂含量为96.1%。Carnosol 是一种有效的核糖体S6激酶 (RSK2) 抑制剂,可用于胃癌相关研究,其 IC50 值约为 5.5 μM。Carnosol 是一种 Nrf2 激活剂,增加 Nrf2 的水平以及能促进血红素氧合酶 1 (HMOX1) 的表达。
RSK2 ~5.5 μM (IC 50 ) |
Nrf2
|
It is showed that carnosol has no cytotoxic effects on GES1 cells and 10 μM carnosol strongly suppresses RSK2 activity, but has little effect on any other kinase. Carnosol exerts strong dose-dependent inhibitory effects against RSK2 autophosphorylation and phosphorylation of its substrate ATF1.
Results indicate that Carnosol significantly decreaseS the volume and weight of gastric tumors relative to the vehicle-treated group. Additionally, mice tolerate treatment with carnosol without significant loss of body weight similar to the vehicle-treated group. The phosphorylation of CREB, a direct downstream protein of RSK2, Is strongly inhibited in the carnosol-treated group but the expression of total CREB is relatively unchanged.
药理药效:抑制油脂的过氧化多烯脂肪酸的分解
安全信息
安全说明 | 24/25 |
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WGK Germany | 3 |
海关编码 | 29322090 |
毒害物质数据 | 5957-80-2(Hazardous Substances Data) |
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/01/25 | HY-N0643 | Carnosol | 1 mg | 250元 | |
2024/01/25 | HY-N0643 | 鼠尾草苦内脂 Carnosol | 5957-80-2 | 5mg | 500元 |