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Lapatinib

Lapatinib Suppliers list
Company Name: Henan Tianfu Chemical Co.,Ltd.
Tel: 0371-55170693
Email: info@tianfuchem.com
Products Intro: Product Name:Lapatinib
CAS:231277-92-2
Purity:99% Package:500G;1KG;5KG;25KG
Company Name: Beijing Cooperate Pharmaceutical Co.,Ltd.
Tel: +86-10-60279497 +86(0)15646567669
Email: sales01@cooperate-pharm.com
Products Intro: Product Name:Lapatinib base
CAS:231277-92-2
Purity:98% Package:100G;1KG;5KG;10KG;25KG;50KG;100KG
Company Name: Shenzhen Sendi Biotechnology Co.Ltd.
Tel: 0755-23311925 18102838259
Email: Abel@chembj.com
Products Intro: Product Name:Lapatinib
CAS:231277-92-2
Purity:98% Package:38500/KG
Company Name: Henan DaKen Chemical CO.,LTD.
Tel: +86-371-55541817
Email: inquiry@dakenchem.com
Products Intro: Product Name:Lapatinib
CAS:231277-92-2
Purity:99% Package:100grams;500grams;1kg;5kg;10kg;25kg
Company Name: Guangzhou Isun Pharmaceutical Co., Ltd  Gold
Tel:020-39119399 18927568969
Email:isunpharm@qq.com, isunpharm@hotmail.com
Products Intro:Product Name:Lapatinib
CAS:231277-92-2
Purity:98% Package:25mg; 100mg; 1g; 5g; 25g;100g
Lapatinib Basic information
Indications and Usage Mechanisms of Action
Product Name:Lapatinib
Synonyms:lapatinib;n-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[(2-methylsulfonylethylamino)methyl]-2-furyl]quinazolin-4-amine;4-Quinazolinamine, N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[[[2-(methylsulfonyl)ethyl]amino]methyl]-2-furanyl]-;Lapatinib(TINIBS);Lapatinib Base N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[[[2-(methylsulfonyl)ethyl]amino]methyl]-2-furanyl]-4-Quinazolinamine;N-(3-chloro-4-((3-fluorobenzyl)oxy)phenyl)-6-(5-(((2-(methylsulfonyl)ethyl)amino)methyl)furan-2-yl)quinazolin-4-amine;4-[[3-Chloro-4-(3-fluorobenzyloxy)phenyl]amino]-6-[5-[[(2-methanesulfonylethyl)amino]methyl]furan-2-yl]quinazoline;GSK572016
CAS:231277-92-2
MF:C29H26ClFN4O4S
MW:581.0575432
EINECS:
Product Categories:Molecular Targeted Antineoplastic;anti-neoplastic;Pharmaceutical intermediate;APIs;API;Lapatinib;Anti-cancer&immunity;Inhibitors
Mol File:231277-92-2.mol
Lapatinib Structure
Lapatinib Chemical Properties
CAS DataBase Reference231277-92-2(CAS DataBase Reference)
Safety Information
MSDS Information
Lapatinib Usage And Synthesis
Indications and UsageLapatinib is a drug targeting breast cancer developed by British GlaxoSmithKline Co.
Human ErbB receptors belong to the type I tyrosine kinase (TK) receptor family, including ErbB1 (EGFR), ErbB2 (HER2), ErbB3 (HER3), and ErbB4 (HER4). The ErbB-1 (EGFR) and ErbB-2 (HER-2) receptors are often overexpressed or otherwise altered in cancer patients. Human epidermal growth factor receptor 2 (ErbB-2, HER-2) is known to be a human oncogene closely related with breast cancer. Its high expression in breast cancer often predicts lymph node metastasis and poor tumor differentiation, with poor prognosis. HER-2 is one of the target molecules for breast cancer-specific therapy. Lapatinib can act simultaneously on both Her-1 Her-2. The biological effects of this method inhibiting the proliferation and growth of tumor cells are much larger than only acting on one target. The combination of Lapatinib with Capecitabine is used to treat patients with advanced or metastatic breast cancer with overexpression of human epidermal receptor2, already treated with anthracyclines, paclitaxel, and trastuzumab. Clinical trials have shown that Lapatinib also effectively treats HER2-type cancer patients with Herceptin resistance.
Mechanisms of ActionLapatinib is a tyrosine kinase inhibitor which can effectively inhibit the tyrosine kinase activity of human epidermal growth factor receptors 1 and 2 (ErbB1, ErbB2). It can uniquely act in a variety of ways, ensuring that breast cancer cells cannot receive growth signals. It inhibits intracellular EGFR (ErbB-1) and HER2 (ErbB-2) ATP sites, preventing tumor cell phosphorylation and activation, blocking down-regulation signals through the homogeneity and heterogeneity of EGFR (ErbB-1) and HER2 (ErbB-1) dimerization.
UsesLapatinib Ditosylate (GW572016, GW2016, Tykerb, Tyverb) is a potent EGFR and ErbB2 inhibitor with IC50 of 10.8 and 9.2 nM, respectively.
UsesLapatinib, used in the form of Lapatinib Ditosylate, is a potent EGFR and ErbB2 inhibitor with IC50 of 10.8 and 9.2 nM, respectively.
Usesantineoplastic, tyrosine kinase inhibitor
UsesAn antineoplastic agent used in breast cancer research
Lapatinib Preparation Products And Raw materials
Tag:Lapatinib(231277-92-2) Related Product Information
Nilotinib Imatinib mesylate Phenylacetic acid Nizatidine Diphenyl oxide Methoxy PHENYL RESIN Methoxydiethylborane Lapatinib ditasylate 3-Chloro-4-(3-fluorobenzyloxy)aniline Lapatinib (Trifluoromethoxy)benzene Sunitinib Gefitinib p-(2-Methoxyethyl) phenol PHENYL VALERATE Imatinib Lapatinib ditosylate