PJ34
中文名称 | PJ34 |
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中文同义词 | N-(6-氧代-5,6-二氢菲啶-2-基)-2-(N,N-二甲基氨基)乙酰胺盐酸盐;PJ 34 盐酸盐;PARPL和PARP2抑制剂;化合物PJ34 HYDROCHLORIDE;PJ-34盐酸盐水合物;PJ34 HCL 游离;PJ34 盐酸 |
英文名称 | PJ-34 |
英文同义词 | PJ 34 Hydrochloride;N-(5,6-Dihydro-6-oxo-2-phenanthridinyl)-2-acetamidehydrochloride;PARP Inhibitor VIII, PJ34;PJ-34 hydrate hydrochloride;AcetaMide, N-(5,6-dihydro-6-oxo-2-phenanthridinyl)-2-(diMethylaMino)-, hydrochloride;N-(5,6-Dihydro-6-oxo-2-phenanthridinyl)-2-(diMethylaMino)acetaMide;N-(6-Oxo-5,6-dihydrophenanthridin-2-yl)-2-(N,N-dimethylamino)acetamide hydrochloride;N,N-diMethyl-2-(6-oxo-5,6-dihydrophenanthridin-2-yl)acetaMide hydrochloride |
CAS号 | 344458-15-7 |
分子式 | C17H17N3O2HCl |
分子量 | 0 |
EINECS号 | |
相关类别 | DNA损伤;小分子抑制剂,天然产物;小分子抑制剂;细胞生物学试剂;试剂盒-细胞分析试剂盒;Amines;Aromatics;Heterocycles;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals |
Mol文件 | 344458-15-7.mol |
结构式 |
PJ34 性质
储存条件 | Keep in dark place,Inert atmosphere,Store in freezer, under -20°C |
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溶解度 | H2O:可溶,22mg/mL |
形态 | 白色固体 |
颜色 | 白色至黄色 |
敏感性 | Light Sensitive & Hygroscopic |
稳定性 | 从购买之日起 2 年内保持稳定。 DMSO 或蒸馏水中的溶液可在 -20℃ 下储存长达 3 个月。 |
PARP 110 nM (IC 50 ) |
PARP-2 86 nM (IC 50 ) |
PARP-1 110 nM (IC 50 ) |
PJ34 inhibits the PARP enzyme activity with an IC 50 of 110±1.9 nM. To compare the neuroprotective properties of other PARP inhibitors in PC12 cells, PJ34 is evaluated using by LDH assay. PJ34 treatment also significantly and concentration dependently attenuates cell death at a concentration ranging from 10 -7 to 10 -5 M.
To compare the potency and efficacy with other PARP inhibitors, PJ34 is evaluated at the doses of 3.2 and 10 mg/kg, respectively. PJ34 at the dose of 3.2 mg/kg significantly reduces cortical damage by 33%; however, 10 mg/kg dosing shows reversed effect (17% reduction). PJ34 (25 mg/kg) reduces the levels of TNF-α mRNA in ischemic animals by 70% and these values in treated mice do not differ from that of sham or naive animals. Treatment of ischemic mice with PJ34 reduces the level of E-selectin mRNA by 81% and that of ICAM-1 mRNA by 54%, compared to vehicle-treated ischemic mice.
安全信息
安全说明 | 22-24/25 |
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WGK Germany | 3 |
海关编码 | 29339900 |
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/01/25 | HY-13688 | PJ34 hydrochloride | 5 mg | 300元 | |
2024/01/25 | HY-13688 | PJ34 PJ34 hydrochloride | 344458-15-7 | 10mg | 570元 |