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| | Geclosporin Basic information |
| Product Name: | Geclosporin | | Synonyms: | Geclosporin;(3R,4R)-3-Hydroxy-N-methyl-5-[(E)-1-propenyl]-cyclo(L-Leu-L-Nva-Sar-N-methyl-L-Leu-L-Val-N-methyl-L-Leu-L-Ala-D-Ala-N-methyl-L-Leu-N-methyl-L-Leu-N-methyl-L-Val-);Cyclo(((2S,3R,4R,6E)-3-hydroxy-4-methyl-2-(methylamino)-6-octenoyl)-L-norvalyl-N-methylglycyl-N-methyl-L-leucyl-L-valyl-N-methyl-L-leucyl-L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-L-valyl);Cyclosporin A, 7-L-norvaline-;cyclosporin G;Cyclosporine Impurity G;Cyclosporin Impurity G;CS-2592 | | CAS: | 74436-00-3 | | MF: | C63H113N11O12 | | MW: | 1216.64 | | EINECS: | | | Product Categories: | | | Mol File: | 74436-00-3.mol |  |
| | Geclosporin Chemical Properties |
| Melting point | 196-197° | | alpha | D20 -245° (c = 1.0 in chloroform); D20 -191° (c = 1.04 in methanol) | | Boiling point | 1297.8±65.0 °C(Predicted) | | density | 1.013±0.06 g/cm3(Predicted) | | storage temp. | Hygroscopic, -20°C Freezer, Under inert atmosphere | | solubility | Chloroform (Slightly), Methanol (Slightly) | | pka | 13.32±0.70(Predicted) | | form | Solid | | color | White to Off-White | | Stability: | Hygroscopic | | InChIKey | ZMKGDQSIRSGUDJ-LIAWPGETNA-N |
| | Geclosporin Usage And Synthesis |
| Uses | Cylclosporin G is a derivative of Cyclosporin A (C989900), an immunosuppressant that has revolutionized organ transplantation through its use in the prevention of graft rejection. A group of nonpolar cyclic oligopeptides with immunosupppressant activity. | | Uses | Cylclosporin G is a derivative of Cyclosporin A, an immunosuppressant that has revolutionized organ transplantation through its use in the prevention of graft rejection. A group of nonpolar cyclic oligopeptides with immunosupppressant activity. |
| | Geclosporin Preparation Products And Raw materials |
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