卡培立肽
中文名称 | 卡培立肽 |
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中文同义词 | 卡培立肽;醋酸卡培立肽 89213-87-6;人重组型Α-心房尿钠肽;醋酸卡培立肽;卡培立肽杂质 |
英文名称 | ANP 1-28, HUMAN |
英文同义词 | Atrial natriureticpeptide-28 (huMan) (9CI);Atrial Natriuretic Factor (1-28) (huMan) αhANF, Carperitide;Carperitide Acetate;ATRIAL NATRIURETIC PEPTIDE HUMAN, 1-28;ATRIAL NATRIURETIC PEPTIDE 1-28, HUMAN;ATRIAL NATRIURETIC PEPTIDE (1-28), HUMAN, PORCINE;ATRIAL NATRIURETIC FACTOR 1-28, HUMAN;ATRIAL NATRIURETIC FACTOR (1-28) (HUMAN, CANINE) |
CAS号 | 89213-87-6 |
分子式 | C127H203N45O39S3 |
分子量 | 3080.44 |
EINECS号 | 686-482-9 |
相关类别 | 多肽;多肽原料药;药物多肽;peptide |
Mol文件 | 89213-87-6.mol |
结构式 |
卡培立肽 性质
密度 | 1.55±0.1 g/cm3(Predicted) |
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储存条件 | Store at -20°C |
溶解度 | 水:1mg/mL |
形态 | 冻干粉 |
序列 | H-Ser-Leu-Arg-Arg-Ser-Ser-Cys-Phe-Gly-Gly-Arg-Met-Asp-Arg-Ile-Gly-Ala-Gln-Ser-Gly-Leu-Gly-Cys-Asn-Ser-Phe-Arg-Tyr-OH,(Disulfide bridge: Cys-Cys) |
卡培立肽是由三得利株式会社与宫崎医科大学共同研究合成、生产的由28个氨基酸构成的α型心房钠尿肽。
药理学研究结果表明本药具有扩张血管、利尿作用,临床试验结果表明, 卡培立肽可减轻心脏前、后负荷,增加心脏输出量但不影响心率,对急性心力衰竭具有良好的治疗作用。卡培立肽是通过刺激心肌伸展,由心室内颗粒合成的,然后通过冠静脉分布全身,作用于血管平滑肌和肾脏等组织,调节血压和体内电解质平衡。Carperitide是一种有效的natriuretic peptide receptor (NPR)-A 激动剂,EC50值为10.8 nM。Carperitide用于治疗充血性心力衰竭。Target | Value |
NPR-A
(Cell-free assay) | 10.8 nM(EC50) |
Carperitide (Atrial Natriuretic Peptide (ANP) (1-28), human, porcine) is a diuretic, natriuretic, and vasodilatory peptide hormone originally isolated from mammalian hearts. In cultured porcine endothelial cells the inhibition by porcine ANP (1-28) of immunoreactive endothelin-1 secretion after stimulation with Angiotensin II (Ang II) is paralleled by an increase in the cellular cGMP level. Porcine ANP (1-28) strongly inhibits immunoreactive endothelin-1 secretion in porcine aorta after stimulation with Ang II. ANP is a cardiac hormone involved in electrolyte and fluid homeostasis. The inhibition by ANP of endothelin-1 secretion stimulated by angiotensin II (ANGII) and thrombin using cultured human umbilical-vein endothelial cells. Human ANP (1-28) inhibits immunoreactive (ir)-endothelin-1 secretion and increases cyclic GMP in the human umbilical-vein endothelial cells. In glomeruli from normal rats, Human 125 I-ANP (1-28) binds to a single population of high affinity receptors with a mean equilibrium dissociation constant of 0.46 nM. Human ANP (1-28) binds to the glomerular ANP receptor with high affinity stimulated cGMP accumulation. Human ANP (1-28) markedly stimulates cGMP generation, but not cAMP generation in normal rat glomeruli.
单杂≤1.0%
醋酸根含量5.0%~12.0%
水分含量≤10.0%
肽含量≥80.0%
安全信息
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/01/25 | HY-P1235A | 卡培立肽 Carperitide acetate | 89213-87-6 | 500 μg | 1800元 |
2024/01/25 | HY-P1235A | 卡培立肽 Carperitide acetate | 89213-87-6 | 1 mg | 2800元 |