补骨脂乙素
| 中文名称 | 补骨脂乙素 |
|---|---|
| 中文同义词 | 异补骨脂查尔酮;补骨脂乙素(异补骨脂查尔酮);补骨脂乙素(异补骨脂酮;异补骨脂查尔酮/补骨脂乙素;ISOBAVACHALCONE 异补骨脂查尔酮/补骨脂乙素;补骨酯乙素;异补骨脂查耳酮;异补骨脂查尔酮(标准品) |
| 英文名称 | ISOBAVACHALCONE |
| 英文同义词 | ISOBAVACHALCONE;(E)-1-[2,4-Dihydroxy-3-(3-methyl-2-butenyl)phenyl]-3-(4-hydroxyphenyl)-2-propen-1-one;(E)-4,2',4'-Trihydroxy-3'-prenylchalcone;2',4,4'-Trihydroxy-3'-prenyl-trans-chalcone;Isobacachalcone;2-Propen-1-one,1-[2,4-dihydroxy-3-(3-methyl-2-butenyl)phenyl]-3-(4-hydroxyphenyl)-, (2E)-;(2E)-1-[2,4-Dihydroxy-3-(3-methylbut-2-en-1-yl)phenyl]-3-(4-hydroxyphenyl)prop-2-en-1-one;CS-446 |
| CAS号 | 20784-50-3 |
| 分子式 | C20H20O4 |
| 分子量 | 324.37 |
| EINECS号 | |
| 相关类别 | 中药对照品;标准品;对照品,标准品;植物提取物;对照品;植提标准品;标准品-对照品;PI3K/Akt/mTOR;Akt;mTOR;PI3K;分析试剂标准品;对照品-中药对照品;查尔酮;标准品 -中药标准品;标准品，对照品;合成中间体 |
| Mol文件 | 20784-50-3.mol |
| 结构式 |  |
补骨脂乙素 性质
| 熔点 | 156.8-157.8 °C(Solv: ethyl acetate (141-78-6); hexane (110-54-3)) |
|---|---|
| 沸点 | 549.0±50.0 °C(Predicted) |
| 密度 | 1.243±0.06 g/cm3(Predicted) |
| 储存条件 | Keep in dark place,Inert atmosphere,Store in freezer, under -20°C |
| 溶解度 | 溶于二甲基亚砜 |
| 形态 | 黄色油状 |
| 酸度系数(pKa) | 7.99±0.40(Predicted) |
| 颜色 | 橙黄色 |
IC50: 7.92 μM (OVCAR-8 cell)
Isobavachalcone (6.0-48.0 μM; 72 hours; OVCAR-8, PC3, A549, MCF-7, L-02 and HUVEC cells) treatment inhibits the proliferation of human cancer cells. Isobavachalcone inhibits PC3, A549, MCF-7, L-02 and HUVEC cells growth with IC50 values of 15.06 μM, 32.2 μM, 28.29 μM, 31.61 μM and 31.3 μM, respectively.
Isobavachalcone (0-18 μM; 6 hours; OVCAR-8 and PC3 cells) treatment results in a concentration-and time-dependent down-regulation of the Ser-473 phosphorylation of Akt and GSK3b phosphorylation.
Isobavachalcone (0-18 μM; 72 hours; OVCAR-8 and PC3 cells) treatment causes apoptosis via caspase- and ROS-involved mitochondrial pathway.
Cell Proliferation Assay
| Cell Line: | OVCAR-8, PC3, A549, MCF-7, L-02 and HUVEC cells |
| Concentration: | 6.0-48.0 μM |
| Incubation Time: | 72 hours |
| Result: | Inhibited the proliferation of human cancer cells. |
Western Blot Analysis
| Cell Line: | OVCAR-8 or PC3 cells |
| Concentration: | 0 μM, 6 μM, 12 μM, and 18 μM |
| Incubation Time: | 6 hours |
| Result: | A concentration-and time-dependent down-regulation of the Ser-473 phosphorylation of Akt. GSK3b phosphorylation was also inhibited in a concentration- and time-dependent manner. |
Apoptosis Analysis
| Cell Line: | OVCAR-8 cells and PC3 cells |
| Concentration: | 0 μM, 6 μM, 12 μM, and 18 μM |
| Incubation Time: | 72 hours |
| Result: | Led to dose dependent increase of apoptosis. |
Isobavachalcone (20 mg/kg; intraperitoneal injection; for 0.5-24 hours; female Kunming mice) treatment results in an increase in blood glucose levels, reaching a maximum within 1 hour and maintaining until 4 hours post-dosing.
| Animal Model: | Seven-week-old specific pathogen-free female Kunming mice (18-22 g) |
| Dosage: | 20 mg/kg |
| Administration: | Intraperitoneal injection; for 0.5, 1, 2, 4, 6, 8, 12, 24 hours |
| Result: | Increased in blood glucose levels. |
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/01/25 | HY-13065 | Isobavachalcone | 1 mg | 320元 | |
| 2024/01/25 | HY-13065 | 补骨脂乙素 Isobavachalcone | 20784-50-3 | 5 mg | 840元 |