2,3-二巯基丁二酸
| 中文名称 | 2,3-二巯基丁二酸 |
|---|---|
| 中文同义词 | 间-2,3-二巯基丁二酸;内消旋-2,3-二巯基丁二酸,98%;内消旋-2,3-二巯基丁二酸(>98.0%(T));2,3-二硫代-内消旋酒石酸;二琉基丁二酸(2,3-二巯基丁二酸);2,3-二巯基丁二酸 5G;二锍丁二酸;MESO-2,3-二巯基丁二酸 |
| 英文名称 | Succimer |
| 英文同义词 | (2R,3S)-2,3-diMercaptosuccinic acid;(2R,3S)-rel-2,3-DiMercaptosuccinic acid;Butanedioic acid,2,3-diMercapto-, (2R,3S)-rel-;meso-2,3-Dimercaptosuccinic acid;API Succimer;-rel-2,3-Dimercaptosuccinic acid;(r*,s*)-2,3-dimercaptobutanedioicacid;2,3-dimercapto-,(r*,s*)-butanedioicaci |
| CAS号 | 304-55-2 |
| 分子式 | C4H6O4S2 |
| 分子量 | 182.22 |
| EINECS号 | 206-155-2 |
| 相关类别 | 医药中间体;羰基化合物;有机砌块;标准品;小分子抑制剂，天然产物;原料;小分子抑制剂;医药原料;Organic acids;Inhibitors;抗病毒抗感染类;原料药;API;硫醇类;巯基化合物;医药原料药;有机原料;有机化工原料;医用原料;化工原料;产品;医药原料中间体;生物化工;化工中间体;Analytical Chemistry;Ligands for Pharmaceutical Research;Radiopharmaceutical Chemistry (Chelating Reagents);Building Blocks;Chemical Synthesis;Organic Building Blocks;Sulfur Compounds;Thiols/Mercaptans;BDO;304-55-2 |
| Mol文件 | 304-55-2.mol |
| 结构式 |  |
2,3-二巯基丁二酸 性质
| 熔点 | 196-198 °C (dec.)(lit.) |
|---|---|
| 沸点 | 285.62°C (rough estimate) |
| 密度 | 1.439 (estimate) |
| 折射率 | 1.5220 (estimate) |
| 储存条件 | -20°C |
| 溶解度 | DMSO（微溶）、甲醇（微溶，加热） |
| 酸度系数(pKa) | pK1:2.71;pK2:3.48;pK3:8.89(SH);pK4:10.79(SH) (25°C) |
| 形态 | 粉末 |
| 颜色 | 白色至类白色 |
| 水溶解性 | Soluble in water, and ethanol (25 mg/ml, results in colorless to light yellow, clear). |
| Merck | 14,8865 |
| BRN | 1725150 |
| 稳定性 | 稳定的。易燃。与强氧化剂不相容。 |
| InChIKey | ACTRVOBWPAIOHC-XIXRPRMCSA-N |
| CAS 数据库 | 304-55-2(CAS DataBase Reference) |
| EPA化学物质信息 | Butanedioic acid, 2,3-dimercapto-, (2R,3S)-rel- (304-55-2) |
Succimer is a widely used chelating agent for the treatment of Pb poisoning. Red blood cells (RBCs) from lead exposed animals treated with NAC or Succimer are shown to have significantly higher glutathione (GSH) levels and diminished malondialdehyde (MDA) levels when compare to the lead group. Succimer administration also results in decreased glucose 6-phosphate dehydrogenase (G6PD) activity in RBCs from lead exposed animals. Succimer treatment produces a significant reduction in blood lead levels for both lead exposure conditions: the High Pb-succ group has blood lead levels that are 27% of the blood lead levels of the High Pb group at the end of treatment. Succimer is effective in substantially reducing brain lead, as brain lead levels in the High Pb-succ group are 37% of levels in the High Pb group.
安全信息
| 危险品标志 | Xi |
|---|---|
| 危险类别码 | 36/37/38 |
| 安全说明 | 24/25-36-26 |
| WGK Germany | 2 |
| RTECS号 | WM7650000 |
| F | 10-23 |
| TSCA | Yes |
| 海关编码 | 29309090 |
| 毒害物质数据 | 304-55-2(Hazardous Substances Data) |
| 毒性 | LD50 i.p. in mice: >3000 mg/kg (Friedheim, Corvi) |
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