Β-乙酰基-Γ-O-十六烷基-L-Α-卵磷脂
| 中文名称 | Β-乙酰基-Γ-O-十六烷基-L-Α-卵磷脂 |
|---|---|
| 中文同义词 | Β-乙酰基-Γ-O-十六烷基-L-Α-卵磷脂;化合物 T21547;Β-乙酰基-Γ-O-十六烷基-L-Α-卵磷脂;1-O-十六烷基-2-乙酰基-SN-甘油-3-磷酸胆碱 |
| 英文名称 | Platelet Activating Factor-16 |
| 英文同义词 | L-ALPHA-PHOSPHATIDYLCHOLINE, BETA-ACETYL-GAMMA-O-HEXADECYL;L-ALPHA-PHOSPHATIDYLCHOLINE, BETA-ACETYL-GAMMA-O-ALKYL;C16-02:0 PC;C16PAF;C16 ENANTIOMERIC PAF;1-O-AKYL-2-ACETYL-SN-GLYCERO-3-PHOSPHOCHOLINE;1-O-PALMITYL-2-ACETYL-SN-GLYCERO-3-PHOSPHOCHOLINE;1-O-HEXADECYL-2-O-ACETYL-SN-GLYCERO-3-PHOSPHOCHOLINE |
| CAS号 | 74389-68-7 |
| 分子式 | C26H54NO7P |
| 分子量 | 523.68 |
| EINECS号 | |
| 相关类别 | 脂类;试剂盒-Elisa试剂盒 |
| Mol文件 | 74389-68-7.mol |
| 结构式 |  |
Β-乙酰基-Γ-O-十六烷基-L-Α-卵磷脂 性质
| 熔点 | 247 °C |
|---|---|
| 储存条件 | -20°C |
| 溶解度 | 溶于水或乙醇 |
| 形态 | 冻干粉 |
| 水溶解性 | Soluble to 100 mM in water |
| BRN | 3574588 |
|
Human Endogenous Metabolite
|
ERK
|
MEK
|
C16-PAF (PAF (C16); 0.5-1.5 μM; for 24 hours) elicits significant concentration-dependent neuronal loss in PAFR
−/−
but not PAFR
+/+
cultures. C16-PAF (1 μM) elicits neuronal death in PAFR
−/−
cells infected with EGFP alone.
C16-PAF (1 μM; for 24 hours) activates caspase 7 but not caspase 3 in PAFR
−/−
neurons.
C16-PAF is synthesized by two distinct pathways; the remodeling pathway and the de novo synthesis pathway. C16-PAF acts by binding to a unique G-protein-coupled seven transmembrane receptor.
C16-PAF (1-25 μg/ml; 6, 12, 24 h) inhibits
M. smegmatis
and
M. bovis
BCG growth in a time-dependent manner.
Cell Viability Assay
| Cell Line: | Cerebellar granule neurons (CGNs) from PAFR −/− and PAFR +/+ mice |
| Concentration: | 0.5-1.5 μM |
| Incubation Time: | 24 hours |
| Result: | Elicited significant concentration-dependent neuronal loss in PAFR −/− but not PAFR +/+ cultures in serum-free media. |
Western Blot Analysis
| Cell Line: | CGNs |
| Concentration: | 1 μM |
| Incubation Time: | 24 hours |
| Result: | Activated caspase 7 but not caspase 3 in PAFR −/− neurons. |
安全信息
| 危险品标志 | Xn |
|---|---|
| 危险类别码 | 22-38-40-48/20/22 |
| 安全说明 | 36/37-24/25-22 |
| 危险品运输编号 | UN 1888 6.1/PG 3 |
| WGK Germany | 3 |
| RTECS号 | EC6060000 |
| F | 10-21 |
| 提供商 | 语言 |
|---|---|
|
英文
|
|
|
英文
|
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/01/25 | HY-108635 | Β-乙酰基-Γ-O-十六烷基-L-Α-卵磷脂 C16-PAF | 74389-68-7 | 5mg | 1600元 |
| 2024/01/25 | HY-108635 | Β-乙酰基-Γ-O-十六烷基-L-Α-卵磷脂 C16-PAF | 74389-68-7 | 10mM * 1mLin DMSO | 1840元 |