奎寧定鹽酸鹽

奎寧定鹽酸鹽

中文名称奎寧定鹽酸鹽
中文同义词奎寧定鹽酸鹽;奎尼丁盐酸盐;奎尼丁单盐酸盐一水合物;奎尼丁 盐酸盐 一水合物;盐酸奎尼丁一水合物
英文名称QUINIDINE HYDROCHLORIDE
英文同义词Quinidine hydrochloride monohydrate technical grade;QUINIDINE HYDROCHLORIDE;QUINIDINE HYDROCHLORIDE MONOHYDRATE;QUINIDINE HYDROCHLORIDE MONOHYDRATE CRYSTALLINE;Quinidine monohydrate hydrochloride;Quinidine monohydrochloride monohydrate;6μ-Methoxycinchonan-9-ol hydrochloride monohydrate;QUINIDINE HYDROCHLORIDE ISO 9001:2015 REACH
CAS号6151-40-2
分子式C20H27ClN2O3
分子量378.9
EINECS号628-688-3
相关类别小分子抑制剂;小分子抑制剂,天然产物;InhibitorsBuilding Blocks;QuinolinesCell Signaling Enzymes;Cell Signaling Enzymes;Heterocyclic Building Blocks;Substrates;Xenobiotics and Drug Metabolism;Xenobiotics and Drug Metabolism;and Substrates;Application Index;Biochemicals and Reagents;Building Blocks;C11 to C30;Cell Signaling Enzymes;Chemical Synthesis;Enzymes;Heterocyclic Building Blocks;Inhibitors;Quinolines
Mol文件6151-40-2.mol
结构式奎寧定鹽酸鹽 结构式

奎寧定鹽酸鹽 性质

熔点258-259 C
储存条件Store at -20°C
溶解度DMSO:100mg/mL(263.93mM);水:2.5 mg/mL(6.60 mM)

奎寧定鹽酸鹽 用途与合成方法

Quinidine hydrochloride monohydrate 是一种抗心律失常剂,也是 K+ 通道 (K+ channel) 的有效阻断剂,其 IC50 值为 19.9 μM。Quinidine hydrochloride monohydrate 是一种有效且选择性的细胞色素 P450db (cytochrome P450db) 抑制剂,也可用作疟疾的研究。

IC50: 19.9 μM (K + channel)

Quinidine hydrochloride monohydrate blocks WT mSlo3 (K Ca 5.1) channels with an IC 50 of 19.9±1.41 μM and Hill slope of 1.15±0.15 (n=7). Again, the potency of inhibition by Quinidine hydrochloride monohydrate is higher for F304Y mSlo3 (IC 50 of 2.42±0.60 μM, n=9, P<0.005; Hill slope of 0.98±0.12), but lower with R196Q mSlo3 (IC 50 of 38.4±6.77 μM, n=5, P<0.001; Hill slope of 1.05±0.16). The inhibition of F304Y mSlo3 by Quinidine hydrochloride monohydrate is observed to have some time dependence.

Direct application of Quinidine hydrochloride monohydrate on the sciatic nerve produces a dose-related decrease in amplitude at ascending somato-sensory evoked potential (SSEP) and descending compound muscle action potentials (CMAP) when comparing baseline with other time points, or when comparing the experimental left limb to the right contra-lateral glucose-treated limb. The latencies of SSEPs and CMAP potentials after Quinidine hydrochloride monohydrate applications are increased compare to baseline and the contralateral side.

安全信息

危险品标志Xn,Xi
危险类别码20/21/22-36/37/38
安全说明36-26
危险品运输编号UN 2811 6.1/PG 3
WGK Germany3

MSDS信息

更新日期产品编号产品名称CAS号包装价格
2024/01/25HY-B1302奎寧定鹽酸鹽
Quinidine hydrochloride monohydrate
6151-40-2100mg500元
2024/01/25HY-B1302奎寧定鹽酸鹽
Quinidine hydrochloride monohydrate
6151-40-210mM * 1mLin DMSO550元

奎寧定鹽酸鹽 上下游产品信息

"奎寧定鹽酸鹽"相关产品信息
吡啶盐酸盐 盐酸奎宁 盐酸苯胺 三甲胺盐酸盐 甲胺盐酸盐 奎宁 辛可宁 奎寧定鹽酸鹽 奎尼丁 盐酸辛可宁 辛可尼丁二盐酸盐
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