| Company Name: |
J & K SCIENTIFIC LTD.
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| Tel: |
010-82848833 400-666-7788 |
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jkinfo@jkchemical.com |
| Products Intro: |
Product Name:4-alpha-Phorbol 12,13-Didecanoate >99%
CAS:27536-56-7
Package:1mg, 5mg, 10mg
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| | 4ALPHA-PHORBOL 12,13-DIDECANOATE Basic information |
| Product Name: | 4ALPHA-PHORBOL 12,13-DIDECANOATE | | Synonyms: | 4ALPHA-PDD;4ALPHA-PHORBOL 12-13-DICAPRINATE;4ALPHA-PHORBOL 12,13-DIDECANOATE;4a-Phorbol-12,13-didecanoate;4A-PHORBOL 12,13-DIDECANOATE WEAK PROTEI N KINASE C;4α-phorbol 12-13-dicaprinate;4A-PHORBOL 12,13-DIDECANOATE, 99+%;phorbol (4alpha-) 12,13-didecanoate | | CAS: | 27536-56-7 | | MF: | C40H64O8 | | MW: | 672.93 | | EINECS: | | | Product Categories: | metabolite | | Mol File: | 27536-56-7.mol |  |
| | 4ALPHA-PHORBOL 12,13-DIDECANOATE Chemical Properties |
| storage temp. | -20°C | | solubility | DMSO: soluble | | form | solid | | color | white | | BRN | 2514324 |
| | 4ALPHA-PHORBOL 12,13-DIDECANOATE Usage And Synthesis |
| Uses | 4α-Phorbol 12,13-didecanoate has been used as a transient receptor potential vanilloid 4 (TRPV4) agonist:
- to study its effects on Madin-Darby canine kidney (MDCK) cells
- to study its effects on Ca2+ influx in mice fallopian tubal cells
- to study its effects on hind paw swelling in mice
| | Definition | ChEBI: 4alpha-phorbol 12,13-didecanoate is a phorbol ester that is phorbol in which the hydroxy groups at the cyclopropane ring juction (position 13) and the adjacent carbon (position 12) have been converted to the corresponding decanoate esters. A Trpv4-specific ligand. It has a role as a TRPV4 agonist. It is a phorbol ester, a decanoate ester, a tertiary alpha-hydroxy ketone, a diester and a primary allylic alcohol. | | Biochem/physiol Actions | 4α-Phorbol 12,13-didecanoate is a transient receptor potential vanilloid 4 (TRPV4) agonist. It promotes extracellular calcium influx into the cells. |
| | 4ALPHA-PHORBOL 12,13-DIDECANOATE Preparation Products And Raw materials |
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