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Methimazole

Methimazole Suppliers list
Company Name: Nanjing Gold Pharmaceutical Technology Co. Ltd.
Tel: 025-84209270 15906146951
Email: wgp@nanjing-pharmaceutical.com
Products Intro: Product Name:Methimazole
CAS:60-56-0
Purity:99% Package:50KG;25KG;10KG;5KG;1KG
Company Name: Shenzhen Sendi Biotechnology Co.Ltd.
Tel: 0755-23311925 18102838259
Email: Abel@chembj.com
Products Intro: Product Name:Methimazole
CAS:60-56-0
Purity:99% Package:2090/KG
Company Name: CHANGZHOU TIANHUA PHARMACEUTICAL CO.,LTD.  Gold
Tel:+86-519-82891186,82899734
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Products Intro:Product Name:MethiaMazole
CAS:60-56-0
Purity:EP6|USP32|Electronic Grade Package:1kg;5kg;10kg;25kg
Company Name: Sinfachem Limited  Gold
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Products Intro:Product Name:MethiMazole
CAS:60-56-0
Purity:>99% USP36, EP7 Package:1kg, 5kg, 25kg
Company Name: Suzhou Laihui Biotechnology Co., Ltd.  Gold
Tel:180-1316-0973;185-5122-2740
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Products Intro:Product Name:1-methyl-2-mercapto-imidazol(Methimazole)
CAS:60-56-0
Purity:99% Package:5KG, 25KG
Methimazole Basic information
description Chemical properties Uses Production methods
Product Name:Methimazole
Synonyms:1,3-dihydro-1-methyl-2h-imidazole-2-thion;1,3-dihydro-1-methyl-2H-Imidazole-2-thione;1-methyl-2-mercapto-imidazol;1-methyl-imidazole-2-thio;1-Metylo 2 merkaptoimidazolem;1-metylo2merkaptoimidazolem;2H-Imidazole-2-thione, 1,3-dihydro-1-methyl-;2H-Imidazole-2-thione,1,3-dihydro-1-methyl-
CAS:60-56-0
MF:C4H6N2S
MW:114.17
EINECS:200-482-4
Product Categories:Heterocyclic Compounds;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Bioactive Small Molecules;Building Blocks;Cell Biology;Chemical Synthesis;Heterocyclic Building Blocks;Imidazoles;M;API;TAPAZOLE;Other APIs;Medicine Intermediates;Pharmaceutical intermediates
Mol File:60-56-0.mol
Methimazole Structure
Methimazole Chemical Properties
Melting point 144-147 °C(lit.)
Boiling point 280 °C
Fp 280°C
storage temp. Refrigerator
solubility 200g/l
form Crystalline Powder
color White to slightly cream or pale buff
Water Solubility soluble
Merck 14,5971
BRN 108646
CAS DataBase Reference60-56-0(CAS DataBase Reference)
NIST Chemistry ReferenceMethimazole(60-56-0)
EPA Substance Registry System2H-Imidazole-2-thione, 1,3-dihydro-1-methyl-(60-56-0)
Safety Information
Hazard Codes Xn
Risk Statements 43-62-63-22
Safety Statements 26-27-36-45-36/37
WGK Germany 3
RTECS NI8615000
TSCA Yes
HS Code 29332990
Hazardous Substances Data60-56-0(Hazardous Substances Data)
MSDS Information
ProviderLanguage
Methimazole English
ACROS English
SigmaAldrich English
ALFA English
Methimazole Usage And Synthesis
descriptionMethimazole is an antithyroid medication used in the therapy of hyperthyroidism and Graves disease. It works by making it harder for the body to make thyroid hormone.
It is also known as thiamazole, is a thioamide and a thyroid hormone antagonist which acts by inhibiting the incorporation of iodine into tyrosyl residues of thyroglobulin and, thus, lowering thyroid hormone levels.
It resembles propylthiouracil both in chemical structure and activity.
Methimazole is primarily used for the treatment of hyperthyroidism, by inhibiting the peroxidase system, hindering thyroxine (T4) and tri-triiodothyronine (T3) synthesis, animal experiments show that it can inhibit B lymphocytes synthesizing antibodies, and reduce levels of thyroid stimulating antibodies in blood circulating it can make suppressing T cell function return to normal, it is applicable to hyperthyroidism caused by a variety of factors . Like other various drugs (propylthiouracil), it also has some adverse reactions while it is taken, Including hematologic adverse reactions, primarily neutropenia, hematopoietic dysfunction or disorder, thrombocytopenia, reduction of prothrombin or factor VII ; long-term medication can also cause liver damage,such as cholestatic jaundice and toxic hepatitis ; other skin reactions such as hair loss, itching, rash, dermatitis, lupus erythematosus, as well as some other rare adverse reactions. Also methimazole allows prothrombin time to prolong , and increases serum alkaline phosphatase, aspartate aminotransferase (AST) and alanine aminotransferase (ALT)and causes blood bilirubin and blood lactate dehydrogenase increasing. Therefore, patients in the medication should regularly take blood tests, liver function tests and peripheral blood leukocytes.
The above information is edited by the Chemicalbook of Tian Ye.
Chemical propertiesleaf-shaped crystalline (ethanol), melting point 146-148 ℃, boiling point 280 ℃ (decomposition), soluble in water, soluble in alcohol, chloroform, slightly soluble in ether, benzene.
UsesCarbimazole intermediates.
anti-thyroid drugs.
Production methodsReact amino acetal with methyl isothiocyanate to genarate this product. The product can also be produced from thiocyanate and N-substituted amino acetal.
Chemical PropertiesWhite Solid
UsesMethimazole is a thiourea antithyroid agent that prevents iodine organification, thus inhibiting the synthesis of thyroxine. Antihyperthyroid
Methimazole Preparation Products And Raw materials
Raw materialsMETHYLAMINE-->Potassium thiocyanate-->Methyl isothiocyanate-->2,2-Diethoxyethylamine
Tag:Methimazole(60-56-0) Related Product Information
2-MERCAPTO-1-METHYLIMIDAZOLE Methimazole Glucuronide,Methimazole Thio-b-D-glucuronide,Methimazole Glucuronid,Methimazole Thio--D-glucuronide THIAMAZOL IMPURITY A ETHYL 2-MERCAPTO-1-METHYLIMIDAZOLE-5-CARBOXYLATE 5-(HYDROXYMETHYL)-2-MERCAPTO-1-METHYLIMIDAZOLE,2-Mercapto-1-methylimidazole-5-methanol 1-Methyl-2-imidazolidinethione Methimazole-D3 THIAMAZOL IMPURITY C 2-MERCAPTO-4-METHYLIMIDAZOLE Methimazole Malathion 2-Mercaptoethanol Imidazole 1-Methylimidazole N-(Trimethylsilyl)imidazole 2-Ethylhexyl 10-ethyl-4-[[2-[(2-ethylhexyl)oxy]-2-oxoethyl]thio]-4-methyl-7-oxo-8-oxa-3,5-dithia-4-stannatetradecanoate Mercaptoacetic acid 2-Methylimidazole