AZD 2066
中文名称 | AZD 2066 |
---|---|
中文同义词 | 化合物 T10430 |
英文名称 | (R)-5-(3-chlorophenyl)-3-(1-((4-Methyl-5-(pyridin-4-yl)-4H-1,2,4-triazol-3-yl)oxy)ethyl)isoxazole |
英文同义词 | (R)-5-(3-chlorophenyl)-3-(1-((4-Methyl-5-(pyridin-4-yl)-4H-1,2,4-triazol-3-yl)oxy)ethyl)isoxazole;4-[5-[(1R)-1-[5-(3-Chlorophenyl)-3-isoxazolyl]ethoxy]-4-methyl-4H-1,2,4-triazol-3-yl]pyridine;AZD 2066 (AZD-2066;AZD2066);Pyridine, 4-[5-[(1R)-1-[5-(3-chlorophenyl)-3-isoxazolyl]ethoxy]-4-methyl-4H-1,2,4-triazol-3-yl]- |
CAS号 | 934282-55-0 |
分子式 | C19H16ClN5O2 |
分子量 | 381.82 |
EINECS号 | |
相关类别 | |
Mol文件 | 934282-55-0.mol |
结构式 |
AZD 2066 性质
熔点 | 140-142°C |
---|---|
沸点 | 626.3±65.0 °C(Predicted) |
密度 | 1.39±0.1 g/cm3(Predicted) |
储存条件 | -20°C Freezer, Under inert atmosphere |
溶解度 | 可溶于氯仿(少许)、DMSO(少许)、甲醇(少许) |
酸度系数(pKa) | 1.91±0.10(Predicted) |
形态 | 固体 |
颜色 | 白色至类白色 |
mGluR5
|
AZD 2066 (1-10 μM) inhibits Ca
2+
response, with IC
50
s of 27.2±9.1, 3.56±0.52, 96.2±17.8, and 380±78.0 nM in mGlu5/HEK cells and striatal, hippocampal, and cortical cultures respectively.
AZD 2066 (1-10 μM) inhibits the oscillatory Ca
2+
response which induced by bath application of DHPG, and blocks either DHPG or Quis effects in mGlu5/HEK cells.
AZD 2066 (1-10 μM) has less effective in striatal neurons.
AZD 2066 (0.3-30 mg/kg; p.o.) shows discriminative effects in rats.
Animal Model: | Male Wistar rats (weighing 240-250 g) |
Dosage: | 0.03, 0.1, 0.3, 1, 3, 10, 30 mg/kg |
Administration: | P.o. (60 minutes after administration) |
Result: | Caused full and dose-dependent AZD9272-appropriate responding. |
安全信息
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
---|---|---|---|---|---|
2024/04/30 | HY-110255 | AZD 2066 | 1 mg | 2340元 | |
2024/04/30 | HY-110255 | AZD 2066 AZD 2066 | 934282-55-0 | 5mg | 5850元 |