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TOFOGLIFLOZIN

TOFOGLIFLOZIN Suppliers list
Company Name: Anqing Chico Pharmaceutical Co., Ltd.
Tel: 15380796838
Email: chloewu@chicopharm.cn
Products Intro: Product Name:Tofogliflozin
CAS:1201913-82-7
Purity:99% Package:10g;100g;1kg; 25kg or More
Company Name: Hubei xin bonus chemical co. LTD
Tel: 86-13657291602
Email: linda@hubeijusheng.com
Products Intro: Product Name:TOFOGLIFLOZIN
CAS:1201913-82-7
Company Name: BOC Sciences
Tel: +1-631-485-4226
Email: inquiry@bocsci.com
Products Intro: Product Name:Tofogliflozin hydrate
CAS:1201913-82-7
Purity:>98% Package:25mg Remarks:BOC Sciences also provides custom synthesis services for Tofogliflozin hydrate.
Company Name: career henan chemical co
Tel: +86-0371-86658258 15093356674;
Email: factory@coreychem.com
Products Intro: Product Name:Tofogliflozin (hydrate)
CAS:1201913-82-7
Purity:>=98% Package:1KG;2USD
Company Name: Shaanxi Dideu Medichem Co. Ltd
Tel: +86-029-81148696 +8615536356810
Email: 1047@dideu.com
Products Intro: Product Name:TOFOGLIFLOZIN
CAS:1201913-82-7
Purity:98.0% Package:1KG;4660USD

TOFOGLIFLOZIN manufacturers

  • TOFOGLIFLOZIN
  • TOFOGLIFLOZIN pictures
  • $216.00 / 5mg
  • 2021-12-04
  • CAS:1201913-82-7
  • Min. Order: 1g
  • Purity: 99.99%
  • Supply Ability: 5ton/Month
  • TOFOGLIFLOZIN USP/EP/BP
  • TOFOGLIFLOZIN USP/EP/BP pictures
  • $1.10 / 1g
  • 2021-06-08
  • CAS:1201913-82-7
  • Min. Order: 1g
  • Purity: 99.9%
  • Supply Ability: 100 Tons Min
  • TOFOGLIFLOZIN
  •  TOFOGLIFLOZIN   pictures
  • $4660.00 / 1KG
  • 2020-07-09
  • CAS: 1201913-82-7
  • Min. Order: 1KG
  • Purity: 98.0%
  • Supply Ability: 1T
TOFOGLIFLOZIN Basic information
Product Name:TOFOGLIFLOZIN
Synonyms:Tofogliflozin (hydrate);(1S,3'R,4'S,5'S,6'R)-6-[(4-Ethylphenyl)methyl]-3',4',5',6'-tetrahydro-6'-(hydroxymethyl)spiro[isobenzofuran-1(3H),2'-[2H]pyran]-3',4',5'-triol hydrate (1:1);Tofogliflozin hydrate (1:1);Tofogliflozin hydrate (1:1)-API;Tofogliflozin anyhydrous;UNII-554245W62TTofogliflozin [INN];CSG 452(hydrate);(3S,3'R,4'S,5'S,6'R)-5-[(4-ethylphenyl)methyl]-6'-(hydroxymethyl)spiro[1H-2-benzofuran-3,2'-oxane]-3',4',5'-triol,hydrate
CAS:1201913-82-7
MF:C22H26O6.H2O
MW:404.46
EINECS:
Product Categories:API
Mol File:1201913-82-7.mol
TOFOGLIFLOZIN Structure
TOFOGLIFLOZIN Chemical Properties
storage temp. Store at -20°C
solubility DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 30 mg/ml; Ethanol:PBS (pH7.2)(1:20): 0.05 mg/ml
form A crystalline solid
Safety Information
MSDS Information
TOFOGLIFLOZIN Usage And Synthesis
DescriptionTofogliflozin hydrate, which is a sodium-glucose co-transporter 2 inhibitor, was approved in Japan for the treatment of type 2 diabetes at the same time as luseogliflozin hydrate (XIX). The drug was discovered by Chugai Pharmaceutical and jointly developed with Sanofi-Aventis and Kowa. Tofogliflozin hydrate reduces glucose levels by inhibiting the reuptake of glucose by selectively inhibiting SGLT2, and plays a key role in the reuptake of glucose in the proximal tubule of the kidneys.
SynthesisReduction of commercially available 2-bromoterephtalic acid (268) through the use of trimethoxyborane and borane- THF proceeded in 89% yield to afford diol 269. Subjection of this compound to 2-methoxypropene (270) under acidic conditions generated bis-acetonide 271. This bromide then underwent lithium¨Chalogen exchange followed by exposure to magnesium bromide and treatment with lactone 272 (which was prepared by persilylation of commercially available (3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2Hpyran- 2-one (277). This mixture was worked up with aqueous ammonium chloride and upon treatment with p-TsOH in methanol resulted in spiroacetal 273. Next, global protection of all alcohol functionalities within 273 was affected by reaction with methylchloroformate and DMAP in acetonitrile. The benzyl carbonate within 274 was selectively exchanged via Suzuki coupling with 4-ethylphenylboronic acid (275) to afford methylene dibenzyl system 276. Subsequent treatment with aqueous sodium hydroxide in methanol followed by crystallization from 1:6 acetone and water furnished the desired product tofogliflozin hydrate (XXXIV) in 75% yield.

Synthesis_1201913-82-7

TOFOGLIFLOZIN Preparation Products And Raw materials
Tag:TOFOGLIFLOZIN(1201913-82-7) Related Product Information
Crizotinib Plx-4032 (RG7024) SERGLIFLOZIN Ertugliflozin L-pyroglutamic acid Tofogliflozin 2,3,4,6-Tetrakis-O-trimethylsilyl-D-gluconolactone Acetoxy Empagliflozin Dexrazoxane Acarbose Gliclazide PF-04971729 Teneligliptin Hydrobromide Pioglitazone hydrochloride Sofosbuvir D-Glucitol, 1,5-dideoxy-1,5-epithio-1-C-[5-[(4-ethoxyphenyl)Methyl]-2-Methoxy-4-Methylphenyl]-, (1S)- Dapagliflozin Empagliflozin Canagliflozin