| Company Name: |
SynAsst Chemical.
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| Tel: |
021-60343070 |
| Email: |
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| Products Intro: |
Product Name:4-AcetaMidophenyl 2-hydroxybenzoate
CAS:118-57-0
Purity:96%Min Package:10g 100g 500g
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| Company Name: |
Shandong Wadesen Biotechnology Co. LTD
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| Tel: |
0531-88723173 18596073690 |
| Email: |
1047208234@qq.com |
| Products Intro: |
Product Name:2-HYDROXYBENZOIC ACID 4-(ACETYLAMINO)PHENYL ESTER
CAS:118-57-0
Purity:95%+ HPLC Package:20mg;50mg;100mg Remarks:GYL
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| | 2-HYDROXYBENZOIC ACID 4-(ACETYLAMINO)PHENYL ESTER Basic information |
| | 2-HYDROXYBENZOIC ACID 4-(ACETYLAMINO)PHENYL ESTER Chemical Properties |
| Melting point | 187° | | Stability: | Stable. Incompatible with strong oxidizing agents. | | LogP | 2.562 (est) |
| | 2-HYDROXYBENZOIC ACID 4-(ACETYLAMINO)PHENYL ESTER Usage And Synthesis |
| Chemical Properties | solid | | Originator | Acetaminosal ,ZYF Pharm Chemical | | Uses | Analgesic; antipyretic. | | Definition | ChEBI: Acetaminosalol is a carbonyl compound. | | Manufacturing Process | 2 Methods of producing of acetyl salicylic acid ester of N-acetyl-paminophenol:
1. 65.0 g of N-acetyl-p-aminophenol were slurried with 400 ml of water and
cooled to 10°C. 125 ml of 20% sodium hydroxide were slowly added to the
mixture with stirring, the temperature being maintained 10°-15°C. To the
solution obtained, 75.0 g of acetyl salicylic chloride were added with vigorous
stirring over a period of 0.5 h, the solution being maintained at a temperature of about 10°C. Towards the end of the reaction the pH was checked and
adjusted to greater than 10 by the addition of a small amount of 20% sodium
hydroxide. After all the acid chloride had been added, vigorous stirring was
continued for 0.5 h during which time the crude product separated out. The
acetyl salicylic acid ester of N-acetyl-p-aminophenol was filtered off, washed
thoroughly with water and recrystallised from ethanol.
2. 65.0 g of sodium N-acetyl-p-aminophenol were slurried with 500.0 g of dry
benzene and 80.0 g of acetyl salicylic chloride added. The mixture was heated
under reflux for 4 h and filtered hot. The excess benzene was removed under
vacuum and the crude acetyl salicylic acid ester of N-acetyl-p-aminophenol
crystallized from ethanol. | | Brand name | Acephen (G & W);
Infants’ Feverall (Actavis); Injectapap (Ortho-McNeil);
Neopap (Polymedica); Tylenol (McNeil). | | Therapeutic Function | Analgesic, Antineuralgic, Antirheumatic, Antipyretic |
| | 2-HYDROXYBENZOIC ACID 4-(ACETYLAMINO)PHENYL ESTER Preparation Products And Raw materials |
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