地诺前列素氨丁三醇
中文名称 | 地诺前列素氨丁三醇 |
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中文同义词 | 缓血酸胺盐;前列腺素 F2ΑTRIS 盐;地诺前列素氨丁三醇38562-01-5,工厂零售38562-01-5;地诺前列素氨丁三醇;氨丁三醇地诺前列素;地诺前列素氮三丁醇;地诺前列腺素 氨丁三醇;地诺前列素氨丁三醇 EP标准品 |
英文名称 | Dinoprost tromethamine |
英文同义词 | 583e;7-(3,5-dihydroxy-2-(3-hydroxy-1-octenyl)cyclopentyl)-5-heptenoicacid,tromet;Tromethamine salt;PGF2α (Prostaglandin F2α);Dinoprost TroMethaMine USP;Dinorprost tromethamine;(E,Z)-(1R,2R,3R,5S)-7-[3,5-Dihydroxy-2-[(3S)-(3-hydroxy-1-octenyl)]cyclopentyl]-5-heptenoic acid compound with 2-amino-2-(hydroxymethyl)-1,3-propanediol (1:1)@component of prostin F2 alpha, injectable;Dinoprost compd. with 2-amino-2-(hydroxymethyl)-1,3-propanediol (1:1) |
CAS号 | 38562-01-5 |
分子式 | C24H45NO8 |
分子量 | 475.62 |
EINECS号 | 254-002-3 |
相关类别 | 医药原料药;合成;原料药;前列素类;化工原料;APIs;科研原料;生化试剂;通用生化试剂-脂类 |
Mol文件 | 38562-01-5.mol |
结构式 |
地诺前列素氨丁三醇 性质
熔点 | 100-101° |
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储存条件 | -20°C |
溶解度 | 在水中的溶解度1 mg/mL水溶液在2-8°C下可稳定保存30天,在−0°C下单独保存数月使用等分试样。避免反复冷冻/解冻循环。 |
形态 | 粉末 |
颜色 | 白色 |
Merck | 13,7970 |
BRN | 4087514 |
稳定性 | 吸湿性 |
InChIKey | IYGXEHDCSOYNKY-RZHHZEQLSA-N |
FP Receptor
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Human Endogenous Metabolite
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Dinoprost tromethamine salt (Prostaglandin F2α tromethamine salt; 1 μM; for 24 hours) induces ER stress, autophagy, and apoptosis in goat luteal cells.
Dinoprost tromethamine salt (1 μM; for 24 hours) significantly increases the expression of GRP78 and UPR sensors.
Apoptosis Analysis
Cell Line: | Goat luteal cells |
Concentration: | 1 μM |
Incubation Time: | For 24 hours |
Result: | Significantly increased the apoptotic rate (15.62±3.12%). |
Cell Autophagy Assay
Cell Line: | Goat luteal cells |
Concentration: | 1 μM |
Incubation Time: | For 24 hours |
Result: | There was extensive overlap between LC3 and LAMP1 in luteal cells and autophagolysosomes were formed in goat luteal cells. |
Western Blot Analysis
Cell Line: | Goat luteal cells |
Concentration: | 1 μM |
Incubation Time: | For 24 hours |
Result: | The expression of GRP78 and UPR sensors including cleaved ATF6, phosphorylated-EIF2S1, EIF2S1, ATF4, phosphorylated-IRE1, autophagy-related protein LC3-II, and pro-apoptosis factor cleaved Caspase3 increased significantly in the cells. |
提供商 | 语言 |
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英文
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更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/01/25 | HY-12956A | Dinoprost tromethamine salt | 1 mg | 220元 | |
2024/01/25 | HY-12956A | 地诺前列素氨丁三醇 Dinoprost tromethamine salt | 38562-01-5 | 5mg | 550元 |