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Everolimus

Everolimus Suppliers list
Company Name: Capot Chemical Co.,Ltd.
Tel: +86 (0)571-855 867 18
Email: sales@capotchem.com
Products Intro: Product Name:Everolimus
CAS:159351-69-6
Purity:98%(Min.HPLC) Package:100g;1kg;5kg,10kg,25kg,50kg
Company Name: Sichuan Tuskwei Import and Export Trade Co., Ltd.
Tel: 86-311-83306736
Email: catherine@tuskwei.com
Products Intro: Product Name:Everolimus ada@tuskwei.com whatsapp;8618031153937
CAS:159351-69-6
Purity:97% Package:2USD/1G Remarks:PHARM
Company Name: Dalian Meilun Biotech Co., Ltd.  Gold
Tel:0411-66771943;0411-66771942
Email:sales@meilune.com
Products Intro:Product Name:Everolimus;RAD001
CAS:159351-69-6
Purity:>95%,BR Package:680RMB/20MG Remarks:Meilunbio
Company Name: EASON Chemical Co., LIMITED  Gold
Tel:15157289797 13566878689
Email:info@seasonsbio.com
Products Intro:Product Name:EVEROLIMUS
CAS:159351-69-6
Purity:ICH Package:1g;10g;100g Remarks:Research use
Company Name: Suzhou Unite pharmTech Co., Ltd ,  Gold
Tel:+86-013222993784 +86-512-82177310
Email:sales@unite-pharm.com
Products Intro:Product Name:Everolimus
CAS:159351-69-6
Purity:99% Package:1g,5g,25g
Everolimus Basic information
description
Product Name:Everolimus
Synonyms:23,27-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclohentriacontine, rapamycin deriv;Everolimus solution ;Everolimus, >=98%;42-O-(2-Hydroxyethyl)-rapamycin;Certica;RAD-001;SDZRAD;Rapamycin, 42-O-(2-hydroxyethyl)-
CAS:159351-69-6
MF:C53H83NO14
MW:958.232
EINECS:
Product Categories:Akt;mTOR;PI3K;All Inhibitors;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;Inhibitor;Antineoplastic protein kinase inhibitors;mTOR inhibitor;Certican, Zortress, Afinitor;Anti-cancer&immunity;PI3K/Akt/mTOR;Everolimus
Mol File:159351-69-6.mol
Everolimus Structure
Everolimus Chemical Properties
Melting point NA
Fp 2℃
storage temp. −20°C
Water Solubility Soluble in dimethysulfoxide,ethanol and chloroform. Slightly soluble in water.
Stability:Hygroscopic
Safety Information
Hazard Codes T,Xn,F
Risk Statements 48/25-36-20/21/22-11
Safety Statements 45-36/37-26-16
RIDADR UN 1648 3 / PGII
WGK Germany 2
10
MSDS Information
Everolimus Usage And Synthesis
descriptionEverolimus is a Kinase Inhibitor. It’s brand name is Afinitor. Everolimus is a derivative of the natural macrocyclic lactone sirolimus with immunosuppressant and anti-angiogenic properties.The mechanism of action of everolimus is as a Protein Kinase Inhibitor, and Cytochrome P450 3A4 Inhibitor, and P-Glycoprotein Inhibitor, and Cytochrome P450 2D6 Inhibitor.
In cells, everolimus binds to the immunophilin FK Binding Protein-12 (FKBP-12) to generate an immunosuppressive complex that binds to and inhibits the activation of the mammalian Target of Rapamycin (mTOR), a key regulatory kinase. Inhibition of mTOR activation results in the inhibition of T lymphocyte activation and proliferation associated with antigen and cytokine (IL-2, IL-4, and IL-15) stimulation and the inhibition of antibody production.
Everolimus is a biological therapy treatment for
Advanced breast cancer if you have been through the menopause (post menopausal). You take it with the hormone therapy drug exemestane
Advanced kidney cancer that has come back either during or after treatment.
Neuroendocrine tumours of the pancreas that can't be removed with surgery or have spread (metastatic disease).
Researchers are also looking at everolimus as a treatment for head and neck cancer and cancer of the food pipe (oesophageal cancer).
Chemical PropertiesOff White Solid
UsesMacrolide immunosuppressant; derivative of Rapamycin. Inhibits cytokine-mediated lymphocyte proliferation
UsesEverolimus (RAD001) is an mTOR inhibitor of FKBP12 with IC50 of 1.6-2.4 nM
UsesEverolimus Macrolide immunosuppressant; Everolimus is a derivative of Rapamycin. Everolimus inhibits cytokine-mediated lymphocyte proliferation.
UsesEverolimus is a semi-synthetic macrocyclic lactone prepared from rapamycin by selective alkylation of the 42-hydroxy group with a silyl-protected hydroxyethyl triflate moiety, followed by addition of an ethylhydroxy moiety to provide greater stability and bioavailability. Like all tacrolimus analogues, everolimus binds to receptor protein, FKBP12. The complex then binds to mTOR preventing it from interacting with target proteins. Everolimus is extensively cited in the literature with over 2,000 citations.
DefinitionChEBI: A macrocyclic lactone that is rapamycin in which the hydroxy group attached to the cyclohexyl moiety has been converted to the corresponding 2-hydroxyethyl ether. It is an immunosuppressant and antineoplastic agent.
Everolimus Preparation Products And Raw materials
Tag:Everolimus(159351-69-6) Related Product Information
Everolimus-d4 Ethyl1-butyl-2-piperidinecarbxylate Ethyl pipecolinate DL-PIPECOLINIC ACID TETRAHYDRATE 2-(dibutylamino)acetic acid 1-ACETYL-2-PIPERIDINECARBOXYLIC ACID 1-methyl-piperidine-2-carboxylicacidmethylester N,N-DI-N-PROPYL-L-ALANINE 2-(TETRAHYDRO-PYRAN-2-YL)-ETHYLAMINE Rapamycin Everolimus 1-ETHYL-PIPERIDINE-2-CARBOXYLIC ACID HYDROCHLORIDE D(+)-Pipecolinic acid 1-(2-methylpiperidin-1-yl)acetone Ethyl 1-methylpipecolinate H-HOMOPRO-OME HCL 1-piperidinoacetone