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| | 6-METHYLAMINOPURINE 9-RIBOFURANOSIDE Basic information |
| Product Name: | 6-METHYLAMINOPURINE 9-RIBOFURANOSIDE | | Synonyms: | NSC-29409;6-Methylaminopurine D-riboside;6-Methylaminopurine ribonucleoside;6-Methylaminopurinosine;Adenosine, N-methyl-;(2R,3S,4R,5R)-2-(HydroxyMethyl)-5-(6-(MethylaMino)-9H-purin-9-yl)tetrahydrofuran-3,4-diol;N6-methyladenosine (m6A);N6-Me-rA | | CAS: | 1867-73-8 | | MF: | C11H15N5O4 | | MW: | 281.27 | | EINECS: | 200-001-2 | | Product Categories: | Inhibitors | | Mol File: | 1867-73-8.mol |  |
| | 6-METHYLAMINOPURINE 9-RIBOFURANOSIDE Chemical Properties |
| Melting point | 172 °C | | Boiling point | 649.1±65.0 °C(Predicted) | | density | 1.85±0.1 g/cm3(Predicted) | | storage temp. | Keep in dark place,Sealed in dry,2-8°C | | solubility | DMSO (Slightly), Methanol (Slightly, Heated, Sonicated) | | form | Powder | | pka | 13.12±0.70(Predicted) | | Stability: | Hygroscopic |
| | 6-METHYLAMINOPURINE 9-RIBOFURANOSIDE Usage And Synthesis |
| Description | N6-Methyladenosine is an adenosine analog. It inhibits epinephrine-induced contraction of isolated guinea pig ileum and thoracic aorta when used at a concentration of 10 μM. N6-Methyladenosine (1 mg/kg, i.v.) decreases arterial blood pressure and renal blood flow and increases peripheral resistance in anesthetized dogs. It also inhibits tumor growth in the C3H/ST and C3HB/ST mouse models of spontaneous mammary adenocarcinomas. N6-Methyladenosine is also the most prevelant mRNA modification in eukaryotes and has roles in cell viability and development. | | Uses | N6-Methyladenosine is the most common internal modification of eukaryotic mRNA. The result of this modification is specifically recognized mRNA in the cytoplasm which regulates mRNA stability.N6-Methyladenosine is made when a protein complex containin the writer enzyme METTL3 adds a methyl group to adenosine. Two different eraser enzymes ALKBH5 and FTO can remove a methyl group to turn m6A bach into adenosine. | | Definition | ChEBI: A methyladenosine compound with one methyl group attached to N6 of the adenine nucleobase. |
| | 6-METHYLAMINOPURINE 9-RIBOFURANOSIDE Preparation Products And Raw materials |
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