- Mephenoxalone
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- $1.10 / 1g
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2022-05-14
- CAS:70-07-5
- Min. Order: 1g
- Purity: 99.9% Min
- Supply Ability: 100 Tons
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| | Mephenoxalone Basic information |
| | Mephenoxalone Chemical Properties |
| Melting point | 143-145° | | Boiling point | 364.51°C (rough estimate) | | density | 1.2446 (rough estimate) | | refractive index | 1.4960 (estimate) | | storage temp. | 2-8°C | | solubility | DMSO (Slightly), Methanol (Slightly) | | pka | 12.24±0.40(Predicted) | | form | Solid | | color | White to Off-White | | NIST Chemistry Reference | 2-Oxazolidinone, 5-[(o-methoxyphenoxy)methyl]-(70-07-5) |
| Toxicity | LD50 orally in rats: 3820 ±17 mg/kg (Goldenthal) |
| | Mephenoxalone Usage And Synthesis |
| Originator | Trepidone,Lederle, ,1961 | | Uses | Muscle relaxant, also used as a mild tranquilizer. | | Uses | Mephenoxalone is used as a muscle relaxant, also as a mild tranquilizer. | | Uses | Prostaglandin F2á ethyl amide Lumigan (0.03% bimatoprost ophthalmic solution) | | Definition | ChEBI: Mephenoxalone is a member of methoxybenzenes. | | Manufacturing Process | A mixture of 24.1 g (0.10 mol) of 3-o-methoxyphenoxy-2-hydroxy-1-propyl carbamate and 6.0 g (0.10 mol) of urea was heated rapidly to the temperature range of 180°C to 200°C, and maintained there for five hours. The reaction melt was poured into 50% ethyl alcohol, from which the product crystallized as a white solid. The crude yield was 18.3 g (82%); melting point 131.5% to 137°C. Crystallization from water and 95% alcohol gave 9.0 g (40.3 %) of pure 5-o-methoxyphenoxymethyl-2-oxazolidone; melting point 141°C to 143°C. This melting point was not depressed when the material was mixed with an authentic sample. In additional runs acetone was used instead of ethyl alcohol with equivalent results.
It was found that when the heating time was reduced to three hours and a reaction temperature of 190°C to 200°C was maintained, equivalent yields (40 to 50%) were obtained, but that the yields were appreciably lowered when the heating time was further reduced to two hours. It was also found that when the temperature was lowered to the range of 170°C to 180°C the yield was significantly lowered.
When the material was isolated by extraction with chloroform and distillation,
the yield of pure material was 58.5%. | | Brand name | MI. Lenetran (Marion Merrell Dow). | | Therapeutic Function | Tranquilizer |
| | Mephenoxalone Preparation Products And Raw materials |
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