维生素 B12A
| 中文名称 | 维生素 B12A |
|---|---|
| 中文同义词 | 羟钴胺单盐酸盐;化合物 T13731;维生素 B12杂质13 (维生素 B12 EP 杂质H 盐酸盐) |
| 英文名称 | hydroxocobalamin monohydrochloride |
| 英文同义词 | Einecs 261-772-4;Cobinamide hydroxide dihydrogen phosphate (ester), inner salt 3'-ester with 5,6-dimethyl-1-alpha-D-ribofuranosyl-1H-benzimidazole monohydrochloride;hydroxocobalamin monohydrochloride;Cobinamide, Co-hydroxy-, f-(dihydrogen phosphate), inner salt, 3-ester with (5,6-dimethyl-1-.alpha.-D-ribofuranosyl-1H-benzimidazole-.kappa.N3), monohydrochloride;Cobinamide,Co-hydroxy-, f-(dihydrogen phosphate), inner salt, 3'-ester with(5,6-dimethyl-1-a-D-ribofuranosyl-1H-benzimidazole-kN3), hydrochloride (1:1);Vitamin B12a monohydrochloride;Vitamin B12a hydrochloride >=96% (UV), >=96% (HPLC);Hydroxocobalain onohydrochloride |
| CAS号 | 59461-30-2 |
| 分子式 | C62H89ClCoN13O15P |
| 分子量 | 1381.83 |
| EINECS号 | 261-772-4 |
| 相关类别 | |
| Mol文件 | 59461-30-2.mol |
| 结构式 |  |
维生素 B12A 性质
| 储存条件 | 2-8°C |
|---|---|
| 溶解度 | 20°C，在甲醇中可溶10mg/mL, clear, dark red |
The cobalt atom of hydroxocobalamin binds cyanide and nitric oxide and hydroxocobalamin attenuates vascular responses to NO in vitro .
Treatment with hydroxocobalamin before or after giving LPS attenuates LPS-induced hypotension and increases in plasma RNI and enhances LPS-induced urinary excretion of RNI. Hydroxocobalamin (20 mg/kg i.p.) given to Swiss-Webster mice 30 min before giving LPS (16 mg/kg i.p.) decreases the 24-hr mortality of LPS from 80 to 50% and the 36- and 96-hr mortality from 100 to 60% (hydroxocobalamin).
More than 60% of the mice administered 35 mg/kg (0.63 mmol/kg) of NaSH (LD90) survive (at 24 h) when hydroxocobalamin (0.25 mmol/kg) is given after NaSH administration whereas less than 15% of the mice survive without hydroxocobalamin. Hydroxocobalamin (50–100 μM) or cobalt (50–100 μM) also preventes hepatocyte cytotoxicity induced by NaSH (500 μM). Furthermore, adding hydroxocobalamin 60 min later than NaSH still shows some protective activity.
安全信息
| WGK Germany | 3 |
|---|
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/01/25 | HY-B2209A | Hydroxocobalamin monohydrochloride | 5 mg | 375元 | |
| 2024/01/25 | HY-B2209A | 维生素 B12A Hydroxocobalamin monohydrochloride | 59461-30-2 | 10mg | 600元 |