ChemicalBook >>Podophyllotoxin>>(5R,5aR,8aR,9R)-5,8,8a,9-Tetrahydro-9-hydroxy-5-(3,4,5-trimethoxyphenyl)-furo(3',4':6,7)naphtho[2,3-d]-1,3-dioxol-6(5aH)-one(518-28-5)

(5R,5aR,8aR,9R)-5,8,8a,9-Tetrahydro-9-hydroxy-5-(3,4,5-trimethoxyphenyl)-furo(3',4':6,7)naphtho[2,3-d]-1,3-dioxol-6(5aH)-one(518-28-5)

(5R,5aR,8aR,9R)-5,8,8a,9-Tetrahydro-9-hydroxy-5-(3,4,5-trimethoxyphenyl)-furo(3',4':6,7)naphtho[2,3-d]-1,3-dioxol-6(5aH)-one(518-28-5)
Product IdentificationBack to Contents
【Product Name】

(5R,5aR,8aR,9R)-5,8,8a,9-Tetrahydro-9-hydroxy-5-(3,4,5-trimethoxyphenyl)-furo(3',4':6,7)naphtho[2,3-d]-1,3-dioxol-6(5aH)-one
【Synonyms】

3,4-Dimethoxybenzoic acid
Condylox
Dimethylprotocatechuic acid
Furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one, 5,8,8a,9-tetrahydro-9-hydroxy-5-(3,4,5-trimethoxyphenyl)-, (5R,5aR,8aR,9R)-
Podofilox
【CAS】

518-28-5
【CAS】

93-07-2
【Formula】

C22H22O8
【Formula】

C9H10O4
【Molecular Weight】

414.41
【Molecular Weight】

182.18
【EINECS】

202-215-7
【EINECS】

208-250-4
【RTECS】

DG8598750
【RTECS】

LV2500000
【RTECS Class】

Mutagen
【RTECS Class】

Drug; Mutagen; Reproductive Effector; Natural Product
【Merck】

12,10086
【Merck】

12,7704
【Beilstein/Gmelin】

518285
【Beilstein/Gmelin】

99163
【Beilstein Reference】

5-19-10-00666
【Beilstein Reference】

4-10-00-01460
Physical and Chemical PropertiesBack to Contents
【Appearance】

Light yellow-beige powder.
【Appearance】

Off-white powder.
【Solubility in water】

Very soluble
【Solubility in water】

Insoluble
【Melting Point】

117 - 119
【Melting Point】

188 - 189
【Boiling Point】

303
【Vapor Pressure】

0.00042 (25 C)
【Density】

1.436 g/cm3 (-100 C)
【pKa/pKb】

13.42 (pKa)
【pKa/pKb】

4.35 (pKa)
【Partition Coefficient】

1.99
【Heat Of Vaporization】

57.4 kJ/mol
【Heat Of Combustion】

-4256 kJ/mol
【Usage】

Cytostatic (antimitotic) glucoside.
First Aid MeasuresBack to Contents
【Ingestion】

Never give anything by mouth to an unconscious person. Get medical aid immediately. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.
【Ingestion】

Never give anything by mouth to an unconscious person. Get medical aid. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.
【Inhalation】

Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
【Inhalation】

Get medical aid immediately. Remove from exposure to fresh air immediately. If breathing is difficult, give oxygen. Do not use mouth-to-mouth respiration if victim ingested or inhaled the substance; induce artificial respiration with the aid of a pocket mask equipped with a one-way valve or other proper respiratory medical device.
【Inhalation】

May cause respiratory tract irritation. The toxicological properties of this substance have not been fully investigated.
【Skin】

May cause skin irritation.
【Skin】

Get medical aid immediately. Immediately flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
【Skin】

Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
【Eyes】

May cause eye irritation.
【Eyes】

Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
【Eyes】

Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.
Handling and StorageBack to Contents
【Storage】

Store in a cool, dry place. Keep containers tightly closed.
【Storage】

Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.
【Handling】

Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Do not get in eyes, on skin, or on clothing. Do not ingest or inhale. Use only in a chemical fume hood.
【Handling】

Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation.
Hazards IdentificationBack to Contents
【Ingestion】

Causes gastrointestinal irritation with nausea, vomiting and diarrhea. May cause gastrointestinal tract damage.
【Ingestion】

May cause irritation of the digestive tract. The toxicological properties of this substance have not been fully investigated.
【Inhalation】

Causes irritation of the mucous membrane and upper respiratory tract.
【Skin】

Causes skin irritation. Harmful if absorbed through the skin. Substance is readily absorbed through the skin.
【Eyes】

Causes eye irritation. May cause chemical conjunctivitis.
【Hazards】

Contact with metals may evolve flammable hydrogen gas.
【EC Risk Phrase】

R 36/37/38
【EC Safety Phrase】

S 26 36
【UN (DOT)】

2811
Exposure Controls/Personal ProtectionBack to Contents
【Personal Protection】

Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.
【Respirators】

A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant a respirator's use.
Fire Fighting MeasuresBack to Contents
【Flash Point】

121
【Fire Fighting】

Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Extinguishing media: Use agent most appropriate to extinguish fire. In case of fire use water spray, dry chemical, carbon dioxide, or appropriate foam.
【Fire Fighting】

Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. To extinguish fire use water spray, dry chemical, carbon dioxide, or appropriate foam.
【Fire Potential】

Non-combustible, substance itself does not burn but may decompose upon heating to produce corrosive and/or toxic fumes.
Accidental Release MeasuresBack to Contents
【Small spills/leaks】

Clean up spills immediately, using the appropriate protective equipment. Sweep up, then place into a suitable container for disposal. Avoid generating dusty conditions. Provide ventilation.
Stability and ReactivityBack to Contents
【Disposal Code】

4
【Incompatibilities】

Oxidizing agents.
【Stability】

Stable under normal temperatures and pressures.
【Incompatibilities】

Strong oxidizing agents, strong acids, strong bases.
【Decomposition】

Carbon monoxide, carbon dioxide.
【Decomposition】

Carbon monoxide, irritating and toxic fumes and gases, carbon dioxide.
【Combustion Products】

Fire may produce irritating, corrosive and/or toxic gases.
Transport InformationBack to Contents
【UN Number】

2811
【Hazard Class】

6.1
【Packing Group】

I; II; III
【HS Code】

2918 90 90
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