ChemicalBook >>Docetaxel>>Docetaxel(114977-28-5)

Docetaxel(114977-28-5)

Docetaxel(114977-28-5)
Product IdentificationBack to Contents
【Product Name】

Docetaxel
【Synonyms】

Benzenepropanoic acid, beta-(((1,1-dimethylethoxy)carbonyl)amino)-alpha-hydroxy-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,6,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca(3,4)benz(1,2-b)oxet-9-yl ester, (alphaR,betaS)-
N-Debenzoyl-N-tert-butoxycarbonyl-10-deacetyltaxol
RP-56976
Taxotere
【CAS】

114977-28-5
【Formula】

C43H53NO14
【Molecular Weight】

807.89
【RTECS】

DA4172750
【RTECS Class】

Drug; Human Data
【Merck】

12,3458
【Beilstein/Gmelin】

4290183
【Beilstein Reference】

6-18
Physical and Chemical PropertiesBack to Contents
【Solubility in water】

60 g/L
【Melting Point】

232
【Usage】

Corresponds to the cancer drug taxotere. Influence on microtubule assembly.
First Aid MeasuresBack to Contents
【Ingestion】

If swallowed, wash out mouth with water provided person is conscious. Call a physician.
【Inhalation】

If inhaled, remove to fresh air. If breathing becomes difficult, call a physician.
【Skin】

In case of contact, immediately wash skin with soap and copious amounts of water.
【Eyes】

In case of contact with eyes, flush with copious amounts of water for at least 15 minutes. Assure adequate flushing by separating the eyelids with fingers. Call a physician.
Handling and StorageBack to Contents
【Storage】

Keep tightly closed.
Hazards IdentificationBack to Contents
【Inhalation】

May be harmful if inhaled. Material may be irritating to mucous membranes and upper respiratory tract.
【Skin】

May cause skin irritation. May be harmful if absorbed through the skin.
【Eyes】

May cause eye irritation.
【Ingestion】

May be harmful if swallowed.
【Hazards】

Emits toxic fumes under fire conditions.
【EC Safety Phrase】

22 24/25
Exposure Controls/Personal ProtectionBack to Contents
【Personal Protection】

Protective gloves. Chemical safety goggles.
【Respirators】

Wear dust mask.
【Exposure Effects】

Properties of this material have not yet been prepared. Any recommendations are of a general nature. Many chemicals cause irritation of the eyes, skin, and respiratory tract. In severe cases respiratory tract irritation can progress to ARDS/acute lung injury which may be delayed in onset for up to 24 to 72 hours in some cases Irritation or burns of the esophagus or gastrointestinal tract are also possible if caustic or irritant chemicals are ingested. ALWAYS contact your local poision control authority or medical professional for assistance.
Fire Fighting MeasuresBack to Contents
【Fire Fighting】

Extinguish using Water spray. Carbon dioxide, dry chemical powder, or appropriate foam. Wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes.
Accidental Release MeasuresBack to Contents
【Small spills/leaks】

Sweep up, place in a bag and hold for waste disposal. Avoid raising dust. Ventilate area and wash spill site after material pickup is complete.
Stability and ReactivityBack to Contents
【Stability】

Stable at normal temperatures and pressures.
【Incompatibilities】

Strong oxidizing agents.
【Decomposition】

Carbon monoxide, Carbon dioxide.
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