ChemicalBook >>Leflunomide>>Leflunomide(75706-12-6)

Leflunomide(75706-12-6)

Leflunomide(75706-12-6)
Product IdentificationBack to Contents
【Product Name】

Leflunomide
【Synonyms】

4-Isoxazolecarboxamide, 5-methyl-N-(4-(trifluoromethyl)phenyl)-
5-Methylisoxazole-4-carboxylic acid (4-trifluoromethyl)anilide
5-Methyl-N-(4-(trifluoromethyl)phenyl)-4-isoxazolecarboxamide
Arava
HWA-486
【CAS】

75706-12-6
【Formula】

C12H9F3N2O2
【Molecular Weight】

270.20999999999998
【RTECS】

NY2354200
【Merck】

12,10407
Physical and Chemical PropertiesBack to Contents
【Solubility in water】

Insoluble
【Boiling Point】

289
【Vapor Pressure】

0.0022 (25 C)
【Density】

1.392 g/cm3 (20 C)
【pKa/pKb】

11.45 (pKa)
【Partition Coefficient】

1.95
【Heat Of Vaporization】

52.9 kJ/mol
【Usage】

Used in active moderate to severe rheumatoid arthritis and psoriatic arthritis.
Handling and StorageBack to Contents
【Storage】

Store in original container in a cool dark place.
Hazards IdentificationBack to Contents
【Inhalation】

Remove to fresh air. If not breathing give artificial respiration. If breathing is difficult, give oxygen. Seek medical attention.
【Skin】

Immediately wash skin with soap and copious amounts of water for at least 15 minutes. If irritation persists, seek medical attention.
【Eyes】

Immediately flush eyes with copious amounts of water for at least 15 minutes. Seek medical advice.
【Ingestion】

If swallowed, wash out mouth with water, provided person is conscious. Seek medical advice.
Exposure Controls/Personal ProtectionBack to Contents
【Personal Protection】

Wear self-contained breathing apparatus, rubber boots & heavy rubber gloves.
Fire Fighting MeasuresBack to Contents
【Flash Point】

129
【Fire Fighting】

Extinguish with carbon dioxide, dry chemical powder or appropriate foam. Water spray. Wear self-contained breathing apparatus and protective clothing to prevent contact with the skin and eyes.
Accidental Release MeasuresBack to Contents
【Small spills/leaks】

Sweep-up/absorb in suitable material, place in a container and hold for disposal. Avoid raising dust. Ventilate area and wash spill site after pickup is complete.
Stability and ReactivityBack to Contents
【Combustion Products】

Emits toxic fumes under fire conditions.
Company Name: Zhenjiang Renzhi Biotechnology Co., Ltd.
Tel: 18762678737
Fax:
WebSite: https://www.chemicalbook.com/ShowSupplierProductsList939707/0.htm
Company Name: J & K SCIENTIFIC LTD.
Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
WebSite: http://www.jkchemical.com
Company Name: 3B Pharmachem (Wuhan) International Co.,Ltd.
Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
WebSite: https://www.chemicalbook.com/ShowSupplierProductsList13285/0.htm
Company Name: Chembest Research Laboratories Limited
Tel: 021-20908456
Fax: 021-58180499
WebSite: http://www.BioChemBest.com
Company Name: TCI (Shanghai) Development Co., Ltd.
Tel: 021-67121386
Fax: 021-67121385
WebSite: https://www.tcichemicals.com/CN/zh/
Company Name: BeiJing Hwrk Chemicals Limted
Tel: 0757-86329057 18501085097
Fax: 010-89508210
WebSite: www.hwrkchemical.com
Company Name: Beijing Ouhe Technology Co., Ltd
Tel: 010-82967028 13552068683
Fax: +86-10-82967029
WebSite: http://www.ouhechem.com/
Company Name: Nanjing Chemlin Chemical Co., Ltd
Tel: 025-83697070
Fax: +86-25-83453306
WebSite: www.echemlin.cn