| Product Identification | Back to Contents | 【Product Name】
Colchicine | 【Synonyms】
7-alpha-H-Colchicine
Acetamide, N-(5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo(a)heptalen-7-yl)-(S)-
Benzo[a]heptalen-9(5H)-one
Colchineos
N-Acetyl trimethylcolchicinic acid methyl ether | 【CAS】
64-86-8 | 【Formula】
C22H25NO6 | 【Molecular Weight】
399.44 | 【EINECS】
200-598-5 | 【RTECS】
GH0700000 | 【RTECS Class】
Agricultural Chemical and Pesticide; Drug; Mutagen; Reproductive Effector; Human Data; Primary Irritant | 【Merck】
12,2536 | 【Beilstein/Gmelin】
2228813 | 【Beilstein Reference】
4-14-00-00946 | 【EC Index Number】
614-005-00-6 | 【EC Class】
Very toxic |
| Physical and Chemical Properties | Back to Contents | 【Appearance】
Pale yellow scales or powder; pale yellow needles when crystallized from odorless or nearly so. | 【Solubility in water】
50 g/L | 【Melting Point】
154 - 156 | 【Density】
1.32 g/cm3 | 【pKa/pKb】
12.36(at 20℃) (pKa) | 【Usage】
In research in plant genetics (for doubling chromosomes). | 【Vapor Density】
14 |
| First Aid Measures | Back to Contents | 【Ingestion】
If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid immediately. | 【Inhalation】
Remove from exposure to fresh air immediately. Get medical aid if cough or other symptoms appear. | 【Skin】
Get medical aid if irritation develops or persists. Flush skin with plenty of soap and water. | 【Eyes】
Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately. |
| Handling and Storage | Back to Contents | 【Storage】
Do not store in direct sunlight. Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Store below 40C. | 【Handling】
Wash thoroughly after handling. Use with adequate ventilation. Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation. |
| Hazards Identification | Back to Contents | 【Inhalation】
Causes respiratory tract irritation. | 【Skin】
Causes skin irritation. | 【Eyes】
Causes eye irritation. | 【Ingestion】
May cause gastrointestinal irritation with nausea, vomiting and diarrhea. May cause kidney damage. May cause systemic toxicity with acidosis. Exposure may cause anemia and other blood abnormalities. May produce aplastic anemia, blood pressure depression, body temperature decrease, changes in kidnet tubules, dyspnea, flaccid paralysis without anesthesia, gastrointestinal effects, kidney damage and hemorrhaging, muscle contraction or spasticity, muscle weakness, nausea, vomiting, respiratory stimulation and somnolence. Prolonged ingestion may produce bone marrow depression with agranulocytosis, thrombocytopenia, leukopenia and aplastic anemia may occur with prolonged administration. Lab findings in overdoses have indicated metabolic acidosis, hyponatremia, hypokalemia, bone marrow hypoplasia, thrombocytopenia, granulocytopenia, coagulopathy, and less commonly hemolytic anemia. | 【Hazards】
Stable. | 【UN (DOT)】
2811 |
| Exposure Controls/Personal Protection | Back to Contents | 【Personal Protection】
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure. | 【Respirators】
Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary. | 【Exposure Effects】
May cause bone marrow abnormalities with damage to blood forming tissues. | 【Poison Class】
1* |
| Fire Fighting Measures | Back to Contents | 【Fire Fighting】
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. To extinguish fire use water spray, dry chemical, carbon dioxide, or chemical foam. | 【Fire Potential】
Slight fire hazard. |
| Stability and Reactivity | Back to Contents | 【Stability】
Stable under normal shipping and handling conditions. | 【Incompatibilities】
Strong oxidizing agents. | 【Decomposition】
Nitrogen oxides, carbon monoxide, carbon dioxide. | 【Combustion Products】
Fire may produce irritating, corrosive and/or toxic gases. |
|
| Company Name: |
J & K SCIENTIFIC LTD. |
| Tel: |
010-82848833 400-666-7788 |
| Fax: |
86-10-82849933 |
| WebSite: |
http://www.jkchemical.com |
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