ChemicalBook >>Bufalin>>3-b,14-Dihydroxy-5-beta-bufa-20,22-dienolide(465-21-4)

3-b,14-Dihydroxy-5-beta-bufa-20,22-dienolide(465-21-4)

3-b,14-Dihydroxy-5-beta-bufa-20,22-dienolide(465-21-4)
Product IdentificationBack to Contents
【Product Name】

3-b,14-Dihydroxy-5-beta-bufa-20,22-dienolide
【Synonyms】

3-beta,14-Dihydroxy-5-beta-bufa-20,22-dienolide
5-(3,14-Dihydroxy-10,13-dimethyl-1,2,3,4,5,6,7,8,9,11,12,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl)pyran-2-one
Bufa-20,22-dienolide, 3,14-dihydroxy-, (3-beta,5-beta)-
Bufalin
【CAS】

465-21-4
【Formula】

C24H34O4
【Molecular Weight】

386.53
【RTECS】

EI2962500
【Merck】

12,1493
【Beilstein/Gmelin】

5141601
Physical and Chemical PropertiesBack to Contents
【Appearance】

White solid.
【Solubility in water】

Insoluble
【Melting Point】

242 - 243
【Vapor Pressure】

1.1E-14 (25 C)
【Density】

1.226 g/cm3 (20 C)
【pKa/pKb】

14.74
【Partition Coefficient】

3.42
【Usage】

A cardiotonic steroid isolated from bufo species toads that potently inhibits ouabain-sensitive na+,k+-atpase activity. Induces apoptosis in various human cell lines such as leukemia hl60 and u937 cells by altering the expression of apoptosis-related genes.
Handling and StorageBack to Contents
【Storage】

Store at -20 C, protect from light.
Stability and ReactivityBack to Contents
【Incompatibilities】

Air sensitive.
【Stability】

Stable for a year if stored as directed.
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