| Product Identification | Back to Contents | 【Product Name】
Cyclophosphamide | 【Synonyms】
2-Bis(2-chloroethyl)aminotetrahydro-2H-1,3,2-oxazophosphorine-2-oxide
Cytoxan
N,N-Bis(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorin-2-amine 2-oxide
Procytox | 【CAS】
50-18-0 | 【Formula】
C7H15Cl2N2O2P | 【Molecular Weight】
261.08999999999997 | 【EINECS】
200-015-4 | 【RTECS】
RP5950000 | 【RTECS Class】
Agricultural Chemical and Pesticide; Tumorigen; Drug; Mutagen; Reproductive Effector; Human Data | 【Merck】
12,2816 | 【Beilstein/Gmelin】
11744 | 【Beilstein Reference】
4-27-00-09750 |
| Physical and Chemical Properties | Back to Contents | 【Appearance】
Fine white crystalline powder. Odorless with a slightly bitter taste. | 【Solubility in water】
40 g/L | 【Melting Point】
65 - 66 | 【Boiling Point】
336 | 【Vapor Pressure】
0.0001 (25 C) | 【Density】
1.479 g/cm3 | 【pKa/pKb】
9.91 (pKb) | 【Partition Coefficient】
.63 | 【Heat Of Vaporization】
57.9 kJ/mol | 【Usage】
Medication. Myeloablative agonist. |
| First Aid Measures | Back to Contents | 【Ingestion】
If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. MMEDIATELY transport the victim to a hospital. | 【Inhalation】
IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. IMMEDIATELY call a physician and be prepared to transport the victim to a hospital even if no symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used. | 【Skin】
IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. IMMEDIATELY call a hospital or poison control center even if no symptoms (such as redness or irritation) develop. IMMEDIATELY transport the victim to a hospital for treatment after washing the affected areas. | 【Eyes】
First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop. |
| Handling and Storage | Back to Contents | 【Storage】
Preserve in tight containers between 2 and 32 C. | 【Handling】
All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood. |
| Hazards Identification | Back to Contents | 【Inhalation】
Pneumonitis or interstitial pulmonary fibrosis may occur. | 【Skin】
Extravasation does not produce a local reaction. Alopecia, pigmentation of finger nails and skin may occur. | 【Eyes】
Flushing of the face may occur. Swollen lips may be noted. | 【Ingestion】
Nausea, vomiting, diarrhea, stomatitis, and hemorrhagic colitis have been reported. | 【UN (DOT)】
1851 |
| Exposure Controls/Personal Protection | Back to Contents | 【Personal Protection】
If Tyvek-type disposable protective clothing is not worn during handling of this chemical, wear disposable Tyvek-type sleeves taped to your gloves. | 【Respirators】
Wear a NIOSH-approved half face respirator equipped with a combination filter cartridge, i.e. organic vapor/acid gas/HEPA (specific for organic vapors, HCl, acid gas, SO2 and a high efficiency particulate filter). | 【Exposure Effects】
Agitation, dizziness, tiredness, weakness, and headache may occur. Not recommended in pregnancy or breast-feeding. |
| Fire Fighting Measures | Back to Contents | 【Flash Point】
157 | 【Fire Fighting】
Fires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher. | 【Fire Potential】
This material is probably combustible. |
| Accidental Release Measures | Back to Contents | 【Small spills/leaks】
If you spill this chemical, you should dampen the solid spill material with water, then transfer the dampened material to a suitable container. Use absorbent paper dampened with water to pick up any remaining material. Seal your contaminated clothing and the absorbent paper in a vapor-tight plastic bag for eventual disposal. Wash all contaminated surfaces with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned. |
| Stability and Reactivity | Back to Contents | 【Stability】
Aq solution keeps for a few hr @ room temperature, but hydrolysis occurs above 30 C, removes chlorine atoms; darkens on exposure to light monohydrate sensitive to oxidation, moisture. Monohydrate. | 【Incompatibilities】
Sensitive to exposure to light (darkens) Sensitive to oxidation Incompatible with benzyl alcohol. |
|
| Company Name: |
Adamas Reagent, Ltd. |
| Tel: |
400-6009262 16621234537 |
| Fax: |
021-64823266 |
| WebSite: |
www.tansoole.com |
| Company Name: |
China Langchem Inc. |
| Tel: |
0086-21-58956006 |
| Fax: |
0086-21-58956100 |
| WebSite: |
www.chemicalbook.com/ShowSupplierProductsList19141/0.htm |
| Company Name: |
RYSS TECH LTD |
| Tel: |
400-188-0725 +86 21 34310725 13611771617 |
| Fax: |
+86 21 34311076 |
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www.chemicalbook.com/ShowSupplierProductsList15256/0.htm |
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