| Product Identification | Back to Contents | 【Product Name】
Quinine | 【Synonyms】
6'-Methoxycinchonidine
Chinine
Cinchonan-9-ol, 6'-methoxy-, (8a,9R)- | 【CAS】
130-95-0 | 【Formula】
C20H24N2O2 | 【Molecular Weight】
324.43 | 【EINECS】
205-003-2 | 【RTECS】
VA6020000 | 【RTECS Class】
Mutagen; Reproductive Effector; Human Data | 【Merck】
12,8245 | 【Beilstein/Gmelin】
91867 | 【Beilstein Reference】
5-23-13-00395 |
| Physical and Chemical Properties | Back to Contents | 【Appearance】
Triboluminescent, orthorhombic needles from absolute alcohol. Odorless. An alkaloid derived from the bark of the cinchona tree. | 【Solubility in water】
Slightly soluble | 【Melting Point】
176 | 【pKa/pKb】
4.87 (pKb) | 【Usage】
Used as an antimalarial drug. | 【Refractive Index】
1.625 (15 C) |
| First Aid Measures | Back to Contents | 【Ingestion】
If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid immediately. | 【Inhalation】
Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid. | 【Skin】
Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. | 【Eyes】
Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately. |
| Handling and Storage | Back to Contents | 【Storage】
Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Store below 40C. | 【Handling】
Wash thoroughly after handling. Use only in a well ventilated area. Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation. |
| Hazards Identification | Back to Contents | 【Inhalation】
May cause respiratory tract irritation. | 【Skin】
Causes skin irritation. May cause allergic contact dermatitis. | 【Eyes】
Causes eye irritation. Contact with the eyes causes eyes to become swollen, watery, and exude a sticky viscous liquid which forms yellowish crusts. Causes visual disturbances including: blurred vision, disturbed color perception, photophobia, diplopia, night blindness, constricted visual fields, mydriasis, and possibly blindness. | 【Ingestion】
May cause gastrointestinal irritation with nausea, vomiting and diarrhea. May cause kidney damage. May cause central nervous system depression, characterized by excitement, followed by headache, dizziness, drowsiness, and nausea. Advanced stages may cause collapse, unconsciousness, coma and possible death due to respiratory failure. Ingestion may produce visual and hearing disturbances. Human systemic effects by ingestion may include: visual field changes, tinnitus, and nausea or vomiting. | 【EC Risk Phrase】
R 22 42/43 | 【EC Safety Phrase】
S 22 36/37 45 | 【UN (DOT)】
3335 |
| Exposure Controls/Personal Protection | Back to Contents | 【Personal Protection】
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure. | 【Respirators】
Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary. | 【Exposure Effects】
Chronic ingestion may cause effects similar to those of acute ingestion. | 【Poison Class】
3 |
| Fire Fighting Measures | Back to Contents | 【Fire Fighting】
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Extinguishing media: Use agent most appropriate to extinguish fire. | 【Fire Potential】
Slightly flammable. |
| Stability and Reactivity | Back to Contents | 【Disposal Code】
3 | 【Stability】
Stable under normal temperatures and pressures. May discolor on exposure to light. | 【Incompatibilities】
Strong oxidizing agents - light. | 【Decomposition】
Nitrogen oxides, carbon monoxide, carbon dioxide, nitrogen. |
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