产品属性:
产品名称 | 规格 | CAS号 | 型号 |
Flurbiprofen-d3 | 500 μg 1 mg 5 mg | 1185133-81-6 | EY-Y0164458 |
Cas No.1185133-81-6
别名 N/A
化学名 N/A
分子式 C15H10D3FO2
分子量 247.3
溶解度 DMF: 25 mg/ml,DMSO: 10 mg/ml,Ethanol: 25 mg/ml,PBS (pH 7.2): 0.9 mg/ml
储存条件 Store at -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述:
Flurbiprofen-d3 is intended for use as an internal standard for the quantification of flurbiprofen by GC- or LC-MS. Flurbiprofen is a non-selective COX inhibitor (IC50s = 0.04 and 0.51 μM for COX-1 and COX-2, respectively).1 In vivo, flurbiprofen (0.3-4.8 mg/kg, p.o.) reduces carrageenan-induced hind paw edema and yeast-induced fever in rats.2 Flurbiprofen reduces plasma fibrinogen levels and arthritic score in a rat model of adjuvant-induced arthritis. It also reduces tumor weight and prostaglandin production and increases survival in a WHT-NC mouse xenograft model when administered at a dose of 5 mg/kg.3 Formulations containing flurbiprofen have been used to manage pain and inflammation associated with arthritis.
1.Barnett, J., Chow, J., Ives, D., et al.Purification, characterization and selective inhibition of human prostaglandin G/H synthase 1 and 2 expressed in the baculovirus systemBiochim Biophys. Acta.1209(1)130-139(1994) 2.Glenn, E.M., Rohloff, N., Bowman, B.J., et al.The pharmacology of 2-(2-fluoro-4-biphenylyl)propionic acid (flurbiprofen). A potent non-steroidal anti-inflammatory drugAgents Actions3(4)210-216(1973) 3.Bennett, A., Houghton, J., Leaper, D.J., et al.Tumour growth and response to treatment: Beneficial effect of the prostaglandin synthesis inhibitor flurbiprofen [proceedings]Br. J. Pharmacol.63(2)356P-357P(1978)
关键字: 1185133-81-6;C18H26N4O5;Flurbiprofen-d3;
上海一研生物科技有限公司Shanghai yiyan bio-technology Co. Ltd.主要从事免疫学、分子生物学和常规生化试剂等为一体的科研产品销售企业,公司自成立以来,秉承""全心全意服务于科研工作者""的企业理念,立足生物科技领域,运用生物技术和科研试剂,发展现代生物科技,为各类大中小医院及其它医疗机构、高等院校、科研院所、企事业单位提供优质的产品,服务生物科技领域的科学研究人员。
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