产品属性：
产品名称 | 规格 | CAS号 | 型号 |
Citrinin | 1mg 5mg 10mg | 518-75-2 | EY-Y0165472 |
Cas No.518-75-2
别名 NSC 186
化学名 (3R,4S)-4,6-dihydro-8-hydroxy-3,4,5-trimethyl-6-oxo-3H-2-benzopyran-7-carboxylic acid
分子式 C13H14O5
分子量 250.3
溶解度 ≤2mg/ml in ethanol;20mg/ml in DMSO;20mg/ml in dimethyl formamide
储存条件 Store at -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述：
Citrinin is a mycotoxin originally isolated from P. citrinum that is also produced by a variety of other fungi that are found as contaminants in human foodstuffs and animal feeds.
In vitro: Previous study found that exposure of HEK293 cells to citrinin led to an arrest of cell cycle G2/M in a concentration-dependent increase. Citrinin treatment could also elevate the expression levels of p53 and p21 proteins, yet attenuate the signals of phosphorylated cell division cycle 2. Moreover, treating HEK293 with citrinin could increase both the value of mitotic index and the population of cells, indicating that arrest of citrinin -induced cell cycle occurred mainly during the mitotic phase [1].
In vivo: Previous study showed that citrinin acted as a nephrotoxin in all tested animal species, but its acute toxicity varied in different species. The 50% lethal dose for ducks is 57 mg/kg; for chickens it is 95 mg/kg; and for rabbits it is 134 mg/kg. In murine kidneys, citrinin could also synergistically act with ochratoxin A to depress RNA synthesis [2].
Clinical trial: Up to now, there is no clinical data reported.
References:
[1] Chang CH, Yu FY, Wu TS, Wang LT, Liu BH. Mycotoxin citrinin induced cell cycle G2/M arrest and numerical chromosomal aberration associated with disruption of microtubule formation in human cells. Toxicol Sci. 2011 Jan;119(1):84-92.
[2] J. W. Bennett and M. Klich. Mycotoxins. Clin.Microbiol.Rev. 16(3), 497-516 (2003).
关键字： 518-75-2;C13H14O5;Citrinin;
上海一研生物科技有限公司Shanghai yiyan bio-technology Co. Ltd.主要从事免疫学、分子生物学和常规生化试剂等为一体的科研产品销售企业，公司自成立以来，秉承""全心全意服务于科研工作者""的企业理念，立足生物科技领域，运用生物技术和科研试剂，发展现代生物科技，为各类大中小医院及其它医疗机构、高等院校、科研院所、企事业单位提供优质的产品，服务生物科技领域的科学研究人员。
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