别名
Dipeptidylpeptidase IV Inhibitor IV, K579 - CAS 440100-64-1 - Calbiochem,(S)-1-(4-Methyl-1-(2-pyrimidinyl)-4-piperidylamino)acetyl-2-pyrrolidinecarbonitrile, DPP IV Inhibitor IV
溶解性
1 M HCl: 16 mg/mLDMSO: 32 mg/mLethanol: 6.5 mg/mL
一般描述
A cyanopyrrolidine compound that acts as a potent DPP IV inhibitor (IC50 = 3, 5, 8, and 8 nM in inhibiting rat, human, monkey, and canine DDP IV, respectively). Oral administration of K579 in rats in vivo has been shown to reduce blood DPP IV activity and augment GLP-1 and insulin response after glucose intake and significantly reduce plasma glucose concentration. Please note: 328.4 is the anhydrous molecular weight; please refer to the vial label for the lot-specific hydration and molecular weight.
其他说明
Please note: 328.4 is the anhydrous molecular weight; please refer to the vial label for the lot-specific hydration and molecular weight. Takasaki, K., et al. 2004. Eur. J. Pharmacol.505, 237.Takasaki, K., et al. 2004. Eur. J. Pharmacol.486, 335.Takasaki, K., et al. 2004. J. Pharmacol. Sci.95, 291.
Sigma-Aldrich西格玛奥德里奇(上海)贸易有限公司
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