别名
tert-Butyl 1-amino-3,6,9,12-tetraoxapentadecan-15-oate,H2N-PEG4-CH2CH2COOtBu,H2N-dPEG(4)-CO-OtBu
应用
This heterobifunctional, PEGylated crosslinker features an amino group at one end and t-butyl-protected carboxyl group at the other, which can be deprotected with acidic conditions. The hydrophillic PEG linker facilitates solubility in biological applications. Amino-PEG4-t-butyl ester can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC® molecules) for targeted protein degradation.
其他说明
Real-time monitoring of vesicle pH in an endocytic pathway using an EGF-conjugated two-photon probeDevelopment of Substrate-Selective Probes for Affinity Pulldown of Histone DemethylasesA bisphosphonate tweezers and clickable PEGylated PAMAM dendrons for the preparation of functional iron oxide nanoparticles displaying renal and hepatobiliary elimination
Sigma-Aldrich西格玛奥德里奇(上海)贸易有限公司
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