Host:Rabbit
Target Protein:phospho-p107 (Ser975)
IR:Immunogen Range:PG(P-S)PR
Clonality:Polyclonal
Isotype:IgG
Entrez Gene:5933
Swiss Prot:P28749
Source:KLH conjugated Synthesised phosphopeptide derived from human RBL1 around the phosphorylation site of Ser975:PG(P-S)PR
Purification:affinity purified by Protein A
Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background:The pocket protein family consists of three structurally and functionally related proteins, Rb (retinoblastoma), p107, and p130. This family of tumor suppressors function to regulate important cellular transcription factors, such as the E2F family. The E2F proteins regulate the expression of genes whose products are important for cell cycle progression. The inactivation Rb is catalyzed by CDK phosphorylation thereby releasing E2F during the G1-S phase cellular progression. Unchecked inactivation of Rb in G1 phase has been indicated as a universal mechanism underlying cellular transformation . While Rb has been the most studied among the pocket proteins, p107 and p130 have also been shown to be key regulators of E2F. Several studies have also provided evidence that p107/p130 provide different functions in E2F regulation than does Rb. Rb, p107, and p130 each contain a conserved 'A/B pocket', which is the target of several viral oncoproteins, namely SV40 large T-antigen and adenovirus E1A. There are two isoforms.
Size:50ul
Concentration:1mg/ml
Applications:WB(1:200-1000)
ELISA(1:5000-10000)
IHC-P(1:100-500)
IHC-F(1:100-500)
IF(1:100-500)
Cross Reactive Species:Human
Mouse
Rat
Dog
Pig
Cow
Horse
Sheep
本品仅供科研使用。不能用于人和动物治疗等其它临床诊断用！
关键字： RBL1;Cellular protein 107;CP107;PRB1;RBL1_HUMAN;phospho Ser975;phospho-p107;磷酸化视网膜母细胞瘤样蛋白p107抗体;
上海沪震实业有限公司是一家集研发、生产和销售于一体的生命科学实验室产品生物科技企业。主营产品：试剂盒，ELISA试剂盒，抗体，重组蛋白，血清，胎牛血清，细胞，原代细胞 细胞培养试剂，常用生化试剂。