Rabbit Anti-AR/Androgen receptor Polyclonal Antibody
DATASHEET
Host:Rabbit
Target Protein:AR/Androgen receptor
IR:Immunogen Range:825-919/919
Clonality:Polyclonal
Isotype:IgG
Entrez Gene:367
Swiss Prot:P10275
Source:KLH conjugated synthetic peptide derived from human Androgen receptor isoform 2:825-919/919
Purification:affinity purified by Protein A
Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background:The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract causes spinal bulbar muscular atrophy (Kennedy disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Two alternatively spliced variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]
Size:50ul
Concentration:1mg/ml
Applications:ELISA(1:5000-10000)
IHC-P(1:100-500)
IHC-F(1:100-500)
IF(1:100-500)
Cross Reactive Species:Human
Mouse
Rat
Chicken
Pig
Cow
Horse
Rabbit
Sheep
本品仅供科研使用。不能用于人和动物治疗等其它临床诊断用!
关键字: AR/Androgen receptor;Androgen receptor is;Androgen receptor (d;AIS;SMAX1;NR3C4;SBMA;ANDR_HUMAN;
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