Professional Supplier Of High Quality Bortezomib CAS:179324-69-7 from China
Professional Supplier Of High Quality Anti-Cancer API Bortezomib CAS:179324-69-7 from China
Synonyms: Velcade;DPBA;Proteasomal Inhibitor XXII, PS-341;PS341;MG-341;MG341;LDP-341;LDP341;BTZ;MLN-341;MLN341;Pyz-Phe-boroLeu
Chemical Name: [(1R)-3-Methyl-1-[[(2S)-1-oxo-3-phenyl-2-[(pyrazinylcarbonyl)amino]propyl]amino]butyl]-boronic acid;(R)-3-Methyl-1-((S)-3-phenyl-2-(pyrazine-2-carboxamido)propanamido)butylboronic acid
Molecular Formula: C19H25BN4O4
Molecular Weight: 384.24
Appearance: White or off-white crystalline powder
E.E Value (HPLC): 99.5% Min.
Assay(HPLC): 99.5% Min.
Bortezomib is a selective and robust 26S proteasome inhibitor, that is a boronic acid dipeptide derivative. Human pancreatic cancer cell studies demonstrate Bortezomib to inhibit the PKR-like endoplasmic reticulum (ER) kinase and enhance ER stress, leading to apoptosis. Studies suggest that Bortezomib affects the gene expression of WT1, and blocks the function of human plasmacytoid DCs through the inhibition of intracellular trafficking of Toll-like receptors and modification of the ER homeostasis. Additionally, Bortezomib has been reported to inhibit necrosis and cell proliferation, and downregulate metastatic gene expression.
关键字: Bortezomib
凯立德生物医药是一家专门从事化学定制合成,医药中间体以及新药研发的外向型企业。公司坚持以科技创新为动力,以市场需求为导向,产品涵盖医药原料,医药中间体,天然产物,手性化合物,药物研究试剂等。同时致力于为国内外知名药企,科研机构及高校提供新型和高附加值的医药原料、医药中间体及天然产物的订制合成服务。
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ChemLeader Biomedical is a professional manufacturer and supplier of New Advanced Pharmaceutical Intermediates, Active Pharmaceutical Ingredients (API) & Drug Impurities.
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