高车前素; 4',5,7-三羟基-6-甲氧基黄酮

Product Name: Hispidulin(Dinatin)

CAS Number: 1447-88-7

Chemical Name: 4',5,7-Trihydroxy-6-methoxyflavone;5,7-Dihydroxy-2-(4-hydroxyphenyl)-6-methoxy-4H-1-benzopyran-4-one; Scutellarein 6-methyl ether

Formula: C₁₆H₁₂O₆

M.Wt: 300.27

Purity:>98%

Biological Activity:

Partial positive allosteric modulator at the benzodiazepine receptor (IC50 = 1.3 μM for inhibition of flumazenil binding); natural sage flavone. Stimulates GABA-induced chloride currents in Xenopus oocytes expressing α1-, α2-, α3-, α5- or α6-β2 γ2S GABAA receptors. Brain penetrant; oral administration reduces seizures in a gerbil model of epilepsy. Also has antifungal, antiproliferative, antioxidant and antithrombotic properties.