Applications of Meclofenoxate hydrochloride

Meclofenoxate hydrochloride(MecloCl), an ester of dimethylethanolamine (DMAE) and 4-chlorophenoxyacetic acid (pCPA), has been shown to improve memory, have a mentally stimulating effect, and improve general cognition. IC50 value: Target: nootropic Meclofenoxate, administered in a dose of 50 mg/kg twice daily for 7 days using the maze-training method, increased the number of responses to the conditioned stimulus, when retention tests were made 24 hours and 7 days after training, whereas citicholine, applied in the same way in a dose of 10 mg/kg, shortened the latency of the responses with reinforcement during the training and increased the number of correct responses to the conditioned stimulus in retention tests 7 days after the training[1]. Meclofenoxate appears to increase the consolidation of new information into long-term memory, but does not affect other aspects of remembering[2].

Meclofenoxate hydrochloride is a psychostimulant in the nootropic agent group available in capsule and tablet formulations approved for traumatic cataphora, alcoholic poisoning, anoxia neonatorum, and children's enuresis in China. Although these 2 generic formulations are marketed in China, information regarding their pharmacokinetics and bioequivalence in humans has not been published. Meclofenoxate hydrochloride appears to increase the consolidation of new information into long-term memory. Meclofenoxate does not affect other aspects of remembering. Meclofenoxate is found that significantly more of the subjects receiving meclofenoxate reportes an increased level of mental alertness.

The applications of is Meclofenoxate hydrochloride:

1.Memory decline through aging

2. Dementia and Alzheimer’s (clinically)

3. Brain damage or injuries

4. Alcohol or drug abuse symptoms and effects

5. Promote the metabolism of brain

References

[1] Mosharrof AH, et al. Effects of meclofenoxate and citicholine on learning and memory in aged rats. Acta Physiol Pharmacol Bulg. 1987;13(4):17-24.
[2] Marcer D, et al. The differential effects of meclofenoxate on memory loss in the elderly. Age Ageing. 1977 May;6(2):123-31.
[3] Daniel A. Haas, Christine L. Quinn, in Pharmacology and Therapeutics for Dentistry (Seventh Edition), 2017.