Uses and Possible Side Effects of Docetaxel

Docetaxel works by disrupting the microtubular network in cells, which is essential for cell division and other normal cellular functions. Docetaxel interferes with the function of microtubules, resulting in inactive microtubule bundles, causing cells to die.

Uses

Approved in treatment of breast cancer, non-small cell lung cancer, advanced stomach cancer, head and neck cancer and metastatic prostate cancer.
Also being investigated to treat small cell lung, ovarian, bladder, and pancreatic cancers, soft tissue sarcoma and melanoma.

Note:  If a drug has been approved for one use, physicians may elect to use this same drug for other problems if they believe it may be helpful.

How to Take Docetaxel

Docetaxel is given by intravenous (IV, into a vein) infusion, usually over an hour. The dosage and schedule are determined by the person's size and type of cancer. It can be given alone or with other drugs. You will be given a corticosteroid prior to the infusion to prevent severe fluid retention and allergic reactions. The steroid be given in a pill form or by IV, which will be determined by your healthcare provider.

This medication contains alcohol and may cause intoxication. You should not drive after the infusion until you know how it will affect you.

This medication can cause severe side effects if given to a patient whose liver function is abnormal. Your labs will be closely monitored prior to each dose of docetaxel and the dose may be decreased or held if your liver function is not normal.

Even when carefully and correctly administered by trained personnel, this drug may cause a feeling of burning and pain. There is a risk that this medication may leak out of the vein at the injection site, resulting in tissue damage that can be severe. If the area of injection becomes red, swollen, or painful at any time during or after the injection, notify your care team immediately. Do not apply anything to the site unless instructed by your care team.

Possible Side Effects

There are a number of things you can do to manage the side effects of docetaxel. Talk to your care team about these recommendations. They can help you decide what will work best for you. These are some of the most common or important side effects:

Allergic Reactions

Allergic reactions are possible with this medication. Signs of a reaction can include: shortness of breath or difficulty breathing, swelling of the face, lips, tongue or throat, trouble swallowing, chest pain, rash, flushing, hives or itching or a decrease in blood pressure. If you notice any changes in how you feel during the infusion, let your nurse know immediately. The infusion will be slowed or stopped if this occurs.

Fluid Retention

Docetaxel can cause your body to hold too much fluid, which can be a serious side effect. Medications will be given before each treatment to decrease the risk of this side effect. Call your healthcare provider if you do not urinate for more than 12 hours, experience shortness of breath, have an unexpected weight gain, or develop swelling in your hands, feet, ankles or legs.