| Identification | Back Directory | [Name]
Benzenesulfonamide, 4-[2-[2-(ethylthio)-4-oxo-3(4H)-quinazolinyl]ethyl]- | [CAS]
1038061-96-9 | [Synonyms]
COX-2-IN-18
Benzenesulfonamide, 4-[2-[2-(ethylthio)-4-oxo-3(4H)-quinazolinyl]ethyl]- | [Molecular Formula]
C18H19N3O3S2 | [MOL File]
1038061-96-9.mol | [Molecular Weight]
389.49 |
| Chemical Properties | Back Directory | [Boiling point ]
621.3±65.0 °C(Predicted) | [density ]
1.38±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
10.15±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
COX-2-IN-18 (Compound 3) is a potent inhibitor of COX-2. COX-2-IN-18 possesses good COX-2 inhibitory activity (IC50 = 0.775 μM) compared to the reference agent, Celecoxib (IC50 = 0.153 μM). COX-2-IN-18 has the potential for the research of cancer diseases[1]. | [References]
[1] El-Azab AS, et al. Antitumor activity, multitarget mechanisms, and molecular docking studies of quinazoline derivatives based on a benzenesulfonamide scaffold: Cell cycle analysis. Bioorg Chem. 2020;104:104345. DOI:10.1016/j.bioorg.2020.104345 |
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