| Identification | Back Directory | [Name]
17-phenyl trinor Prostaglandin F2α cyclopropyl methyl amide | [CAS]
1138395-10-4 | [Synonyms]
cyclopropylmethylbimatoprost
N-Cyclopropyl Methyl Bimatoprost
17-phenyl trinor Prostaglandin F2α cyclopropyl methyl amide
17-phenyl trinor Prostaglandin F2.alpha. cyclopropyl methyl amide
17-phenyl trinor Prostaglandin F2α cyclopropyl methyl amide Exclusive
N-(cyclopropylmethyl)-7-[3,5-dihydroxy-2-(3-hydroxy-5-phenylpent-1-enyl)cyclopentyl]hept-5-enamide
5-Heptenamide, N-(cyclopropylmethyl)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(1E,3S)-3-hydroxy-5-phenyl-1-penten-1-yl]cyclopentyl]-, (5Z)- | [Molecular Formula]
C27H39NO4 | [MOL File]
1138395-10-4.mol | [Molecular Weight]
441.6 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
Acetonitrile: 3 mg/ml; DMF: 25 mg/ml; DMSO: 25 mg/ml; Ethanol: 50 mg/ml; PBS (pH 7.2): .25 mg/ml | [form ]
A crystalline solid |
| Hazard Information | Back Directory | [Description]
Prostaglandin F2α (PGF2α) activates the FP receptor, promoting smooth muscle contraction and luteolysis. 17-phenyl trinor PGF2α binds the FP receptor on ovine luteal cells with a relative potency of 756% compared to that of PGF2α. It is produced in vivo by the hydrolysis of 17-phenyl trinor PGF2α ethyl amide. 17-phenyl trinor PGF2α ethyl amide is used to reduce intraocular pressure related to glaucoma. 17-phenyl trinor PGF2α cyclopropyl methyl amide is a lipophilic analog of 17-phenyl trinor PGF2α. Amides of PGs may serve as prodrugs, as they are hydrolyzed in certain tissues to generate the bioactive free acid. | [Uses]
N-Cyclopropyl Methyl Bimatoprost?is a useful reagent for developing methods for treating epithelial-related conditions including hair loss. N-Cyclopropyl Methyl Bimatoprost?is also an analog of?Bimatoprost (B386800), an synthetic prostamide and structurally related to prostaglandin F2α. | [References]
[1] CARL B. CAMRAS MD , PHD Edward M B M Nehal Patel MD, PHD , et al. Detection of the free acid of bimatoprost in aqueous humor samples from human eyes treated with bimatoprost before cataract surgery[J]. Ophthalmology, 2004, 111 12: Pages 2193-2198. DOI: 10.1016/j.ophtha.2004.06.028 |
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| Company Name: |
Energy Chemical
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| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
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