| Identification | Back Directory | [Name]
Urea, N-(2-hydroxyethyl)-N'-[4-[4-(8-oxa-3-azabicyclo[3.2.1]oct-3-yl)thieno[3,2-d]pyrimidin-2-yl]phenyl]- | [CAS]
1144075-38-6 | [Synonyms]
mTOR inhibitor 9d
Urea, N-(2-hydroxyethyl)-N'-[4-[4-(8-oxa-3-azabicyclo[3.2.1]oct-3-yl)thieno[3,2-d]pyrimidin-2-yl]phenyl]- | [Molecular Formula]
C21H23N5O3S | [MOL File]
1144075-38-6.mol | [Molecular Weight]
425.5 |
| Hazard Information | Back Directory | [Uses]
mTOR inhibitor-24 (comounp 9d) is a mTOR inhibitor, with IC50s of 0.34 nM (mTOR) and 324 nM (PI3K-α) respectively. mTOR inhibitor-24 inhibtis LNCaP cell proliferation (IC50: 180 nM)[1]. | [References]
[1] Verheijen JC, et al. Discovery of 2-arylthieno[3,2-d]pyrimidines containing 8-oxa-3-azabi-cyclo[3.2.1]octane in the 4-position as potent inhibitors of mTOR with selectivity over PI3K. Bioorg Med Chem Lett. 2010 Jan 1;20(1):375-9. DOI:10.1016/j.bmcl.2009.10.075 |
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