| Hazard Information | Back Directory | [Description]
NSC-670224 is a histone deacetylases-6 (HDAC6) inhibitor and nuclear factor-κB (NF-κB) activation blocker. It has been shown to be toxic to Saccharomyces cerevisiae at low micromolar concentrations, potentially acts via a mechanism of action related to that of tamoxifen (NSC 180973), breast cancer drug | [Uses]
NSC-670224 is toxic to Saccharomyces cerevisiae at low micromolar concentration (LC50: 3.2 μM)[1]. | [References]
[1] Nathaniel B Zuckerman, et al. Structural determination of NSC 670224, synthesis of analogues and biological evaluation. ChemMedChem. 2012 May;7(5):761-5. DOI:10.1002/cmdc.201200038 |
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