| Identification | Back Directory | [Name]
Benzamide, 5-bromo-N-[(1,2-dihydro-4,6-dimethyl-2-oxo-3-pyridinyl)methyl]-3-[[trans-4-(dimethylamino)cyclohexyl]ethylamino]-2-methyl- | [CAS]
1403258-69-4 | [Synonyms]
EZH2-IN-5
Benzamide, 5-bromo-N-[(1,2-dihydro-4,6-dimethyl-2-oxo-3-pyridinyl)methyl]-3-[[trans-4-(dimethylamino)cyclohexyl]ethylamino]-2-methyl- | [Molecular Formula]
C26H37BrN4O2 | [MOL File]
1403258-69-4.mol | [Molecular Weight]
517.51 |
| Hazard Information | Back Directory | [Uses]
EZH2-IN-5 is a potent EZH2 inhibitor with IC50 values of 1.52 nM and 4.07 nM for wild-type and mutant Tyr641 EZH2, respectively[1]. | [IC 50]
EZH2 WT: 1.52 nM (IC50); EZH2 Y641F mutant type: 4.07 nM (IC50) | [References]
[1] Richard Chesworth, et al. Substituted benzene compounds. WO2012142513A1 |
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