| Identification | Back Directory | [Name]
Bromo-PEG4-CH2COOtBu | [CAS]
1807505-29-8 | [Synonyms]
Br-PEG4-CH2-Boc
Br-PEG4-CH2COOtBu
Bromo-PEG4-CH2COOtBu
Bromo-PEG4-CH2CO2tBu
Bromo-peg4-ch2co2tbutyl ester
tert-butyl 14-bromo-3,6,9,12-tetraoxatetradecan-1-oate
3,6,9,12-Tetraoxatetradecanoic acid, 14-bromo-, 1,1-dimethylethyl ester | [Molecular Formula]
C14H27BrO6 | [MDL Number]
MFCD27977496 | [MOL File]
1807505-29-8.mol | [Molecular Weight]
371.26 |
| Chemical Properties | Back Directory | [Boiling point ]
402.2±35.0 °C(Predicted) | [density ]
1.230±0.06 g/cm3(Predicted) | [solubility ]
Soluble in Water, DMSO, DCM, DMF | [form ]
Liquid | [color ]
Light yellow to yellow | [InChI]
InChI=1S/C14H27BrO6/c1-14(2,3)21-13(16)12-20-11-10-19-9-8-18-7-6-17-5-4-15/h4-12H2,1-3H3 | [InChIKey]
PELYBQFWTCXTNW-UHFFFAOYSA-N | [SMILES]
C(OC(C)(C)C)(=O)COCCOCCOCCOCCBr |
| Hazard Information | Back Directory | [Description]
Bromo-PEG4-CH2CO2tBu is a PEG linker containing a bromide group and a t-butyl protected carboxyl group. The hydrophilic PEG spacer increases solubility in aqueous media. The bromide (Br) is a very good leaving group for nucleophilic substitution reactions. The t-butyl protected carboxyl group can be deprotected under acidic conditions. | [Uses]
Br-PEG4-CH2-Boc is a PEG- and Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs[1]. | [IC 50]
PEGs; Alkyl/ether | [References]
[1] Darren H. Wakefield, et al. Poly(vinyl ester) Polymers for In Vivo Nucleic Acid Delivery. US20130121954A1. |
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